39 citations
,
June 1982 in “The BMJ” Blood tests confirmed a baby in the womb had a CMV infection.
38 citations
,
July 2021 in “ACS Nano” This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.
38 citations
,
September 2019 in “Chinese Medical Journal” This review discusses the cardiovascular risks associated with anabolic-androgenic steroid use and reports that, despite known toxic effects, further research is needed to clarify the causality of these risks.
38 citations
,
June 2019 in “International Journal of Molecular Sciences” This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.
38 citations
,
March 2017 in “Expert Opinion on Investigational Drugs” This review examines the potential of bimatoprost for treating various types of eyelash and eyebrow hypotrichosis, discussing its pharmacological properties but providing no new clinical results.
38 citations
,
January 2006 in “Journal of Cellular Biochemistry” This study reported the successful isolation of epithelial stem cells from mouse embryonic skin using a simple culture method, with the cells showing the potential to differentiate into multiple cell types.
38 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This article reviews various topics discussed at a workshop on hair disorders, focusing on hair biology, diagnosis, and challenges in therapy evaluation, without presenting new clinical findings.
37 citations
,
August 2022 in “Frontiers in pharmacology” This study found that oral JAK inhibitors are effective and generally well-tolerated for treating alopecia areata, but high recurrence rates after stopping treatment suggest the need for continuous use.
37 citations
,
February 2019 in “Experimental Dermatology” This study explored the regenerative abilities of the African spiny mouse's skin, revealing more robust wound-induced hair follicle neogenesis compared to laboratory mice and highlighting unique features of its hair and wound response.
37 citations
,
October 2015 in “European Journal of Human Genetics” This study found that a genetic model using SNPs can predict early-onset male-pattern baldness with moderate accuracy, which may assist in decisions about interventions.
37 citations
,
March 2006 in “Regulatory Peptides” This study reports that GLP-1 receptors and proglucagon are expressed in the skin of newborn mice, with GLP-1 potentially playing a role in skin development and hair follicle formation.
37 citations
,
January 2002 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that procyanidin B-2 may promote hair growth by reducing expression and inhibiting translocation of PKC isozymes in murine hair epithelial cells.
36 citations
,
January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
36 citations
,
August 2011 in “Journal of Controlled Release” This review explores the potential of using genetically-manipulated stem cells as both therapeutic agents and gene delivery vehicles for enhanced wound regeneration, but it reports no new clinical results.
35 citations
,
July 2018 in “Cell Reports” This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.
35 citations
,
May 2012 in “Expert Opinion on Pharmacotherapy” This review summarizes current and emerging treatments for common hair loss conditions, highlighting good evidence for androgenetic alopecia but noting the lack of long-term data for alopecia areata and cicatricial alopecias.
35 citations
,
April 2008 in “Human Molecular Genetics” This review discusses advances in using molecular tools from skin biology to manipulate adult stem cells for regenerative medicine and reports no new clinical results.
34 citations
,
September 2020 in “BMC Endocrine Disorders” This review highlights that while dexamethasone may reduce mortality in severe COVID-19, no other drugs have proven effectiveness for treatment, emphasizing the need for clinical trials of existing medications.
34 citations
,
April 2018 in “EMBO journal” This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.
34 citations
,
August 2011 in “Journal of Natural Medicines” This study found that Puerariae Flos extract inhibited testosterone 5α-reductase and promoted hair growth in mouse models, suggesting its potential use for treating androgenic alopecia.
34 citations
,
June 2011 in “Alcoholism: Clinical and Experimental Research” This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.
33 citations
,
January 2017 in “Conservation physiology” This study found that measuring reproductive hormone levels in brown bear hair may effectively support non-invasive genetic sampling, though larger samples or more sensitive techniques are needed for broader application.
33 citations
,
April 2011 in “Journal of Veterinary Internal Medicine” This study found that inhaled fluticasone for 11 months did not adversely affect the immune function or response to vaccination in horses with heaves.
33 citations
,
January 2011 in “Elsevier eBooks” This article reviews the complexity and diverse manifestations of systemic lupus erythematosus, highlighting potential genetic, hormonal, and environmental factors in its pathogenesis without presenting new clinical findings.
33 citations
,
October 2010 in “Journal of Dermatological Science” This study suggests that human and mouse hair follicle stem cells may support nerve repair and provide a practical source of stem cells for neurological therapies.
33 citations
,
April 2009 in “Clinical and Experimental Dermatology” This study observed that psychological factors and serum levels of zinc, folate, and vitamin B12 may contribute to the development of trichodynia.
32 citations
,
December 2018 in “Cytokine” This review discusses the involvement of type I interferons in skin autoimmune and inflammatory diseases but reports no new clinical results.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
32 citations
,
April 2016 in “Journal of Investigative Dermatology” This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.
32 citations
,
February 2016 in “The American journal of dermatopathology/American journal of dermatopathology” This study observed that in primary extramammary Paget disease, carcinoma commonly spreads to significant depths along hair follicles and eccrine ducts, with a maximal depth of 3.6 mm.