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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

Thymosin β4 helps improve skin healing and reduce scarring.

New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.

Some plants with flavonoids may help treat hair loss and promote hair growth.

New chemotherapy drugs cause skin side effects, but treatments like minocycline and tetracycline can help reduce them.

Mice with autoimmune hair loss showed signs of heart problems.

Ephrin-A3 helps increase and speed up hair growth in baby mice.

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Glutamic acid helps increase hair growth in mice.

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

Blocking prolactin increases the activity of secondary hair follicles in cashmere goats.

Transplanting growing hair follicles into scars can help regenerate and improve scar tissue.

Gene therapy shows promise for improving wound healing, but more research is needed for human use.

MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.

Terbinafine can cause hair loss.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

The skin microbiome helps heal wounds and can be targeted to improve healing.