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This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

In this study, researchers successfully derived skin organoids from mouse pluripotent stem cells that spontaneously produce hair follicles, potentially aiding in hair growth research and in vitro drug testing.

This study found that Blimp1+ cells from mice can generate sebaceous gland organoids in vitro, which mimic natural gland traits and may aid in studying acne vulgaris.

This study reported that rapamycin reduced murine cochlear organoid proliferation depending on concentration, but at a 10-nM dose, it significantly increased hair cell differentiation by enriching SOX2+ progenitors while suppressing cells lacking Sox2 at early proliferation stages.

This study found that newborn mouse skin organoids can robustly grow hair in vivo, while adult organoids require specific interventions to restore their hair-forming ability.

In this study, adding CCL2 protein to organoid cultures helped adult skin cells regain the ability to self-organize and regenerate hair follicles, suggesting potential therapeutic applications.

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

This study developed microfluidic-assisted GelMA-MSC/HAD-EPC microspheres that efficiently generated hair follicles in nude mice, suggesting a promising strategy for advancing hair-regenerative medicine.

Using mouse hair follicle organoids, this study demonstrated that BMP4 plays a key role in controlling hair follicle coloration and growth, as well as directing Nestin-positive stem cells towards becoming melanocytes, the pigment-producing cells responsible for hair color.

This study introduces a method for long-term expansion of adult mouse epidermal stem cells in vitro using an organoid culture system that maintains the basal-apical organization.

Researchers created long-lasting, diverse skin organoids from mouse hair follicle stem cells, useful for studying skin.

This research investigated the role of EphA1 in embryonic and adult tissues, generating mouse models suggesting potential links to skin and colon cancer, sepsis, and post-traumatic injury.

In this study, researchers discovered two new signaling pathways that regulate how melanocytes establish pigment patterns in reconstituted hair-bearing skin, offering insights that could inform strategies to prevent hair greying.

This study found that papillary dermal fibroblast progenitors in newborn mouse skin can be isolated and cultured to generate male germline cell precursors, demonstrating their potential through differentiation into cells with meiotic capability.

This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.

In this study, researchers successfully generated hair follicle organoids using human induced pluripotent stem cells (hiPSCs) with collagen I as a microenvironment, demonstrating potential applications in hair regeneration, though fully human organoids require additional approaches.

This study found that Katsuwonus pelamis heart hydrolysates promoted hair growth in human dermal papilla cells, a 3D hair follicle organoid model, and C57BL/6 mice, suggesting its potential as a bioactive hair growth ingredient.

In this study, researchers developed a new photoactivatable Cre recombinase mouse model, DiLiCre, which allows precise light-induced genetic modifications and cell tracing, demonstrating its effectiveness for advancing biological and biomedical research.

This review discusses the potential of 3D cell cultures, particularly Patient-Derived Organoids, in advancing research on liposarcoma by addressing limitations of 2D cultures and animal models but reports no new experimental findings.

This study identified a radio-resistant population of Krt15+ stem cells in the mouse small intestine that can initiate tumors, suggesting potential targets for colon cancer therapy.

This review discusses recent findings on the plasticity and regulation of epithelial stem cells and reports no new experimental results.

This review discusses recent advances in scarless wound healing research, focusing on the roles of mechanobiology and immunology, and reports no new clinical results; the authors highlight the potential of next-generation human skin equivalents in understanding these mechanisms.

This review discusses the formation and maintenance of hair follicles through dynamic cellular changes and signaling pathways, presenting a comprehensive overview but providing no new experimental findings.

This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.

This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.

In this study using mouse models, researchers found that elevated IL-17a in aged olfactory epithelium impairs olfactory function, while IL-17a inhibition promotes regeneration and mitigates age-related decline.

This study presents a new mouse model for investigating chronic graft-versus-host disease, highlighting the role of human thymic tissue in developing multiorgan fibrosis driven by human immune cells.

In this study, mouse models of 22q11.2 deletion syndrome showed that growth issues in small embryonic thymuses were linked to mesenchymal cells, which could be corrected by substituting with normal mesenchyme.

In this study, researchers used patient-derived organoids to model metastasis in colorectal cancer and discovered that cancer cells temporarily switch to a wound-healing program, orchestrated by reduced EZH2 activity and YAP signaling, before spreading to new organs.

This study developed the iCOUNT tool, which provides insights into stem cell behavior by tracking cell division events and molecular consequences in human and mouse neural stem/progenitor cells.