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Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.

Both drugs lower DHT levels, with GI198745 being more effective.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

People with polycystic ovary syndrome have a higher chance of having chronic thyroiditis.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Nitric oxide gel helps heal skin burns faster by improving skin growth, hair regrowth, and blood vessel formation.

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

The current methods for diagnosing polycystic ovary syndrome are too vague and may lead to misdiagnosis and problems in research.

SHBG may be a useful early indicator and treatment target for PCOS.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Improving the environment and cell interactions is key for creating human hair in the lab.

Finasteride helps reduce priapism in sickle cell anemia patients.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Finasteride helps reduce heart issues and improves heart function.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.