103 citations,
November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
98 citations,
February 2007 in “Seminars in Cell & Developmental Biology” Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.
90 citations,
January 2021 in “Clinical Endocrinology” Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.
77 citations,
February 2017 in “Stem Cell Reports” SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.
74 citations,
January 1998 in “Dermatology” Men who think they are losing hair feel worse about themselves, especially if they are younger.
71 citations,
May 2007 in “The FASEB journal” Human hair follicles produce and respond to erythropoietin, helping protect against stress.
71 citations,
January 2004 in “Dermatology” Oral finasteride works better than topical minoxidil for hair growth, both are safe.
67 citations,
July 2006 in “Clinics in Dermatology” Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.
63 citations,
September 1987 in “Journal of Biological Chemistry” Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
60 citations,
October 2014 in “Journal of the American Academy of Dermatology” Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.
60 citations,
September 2001 in “Journal of the American Academy of Dermatology” Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.
50 citations,
December 2013 in “Stem Cells” Stem cell niches are adaptable and key for tissue maintenance and repair.
40 citations,
February 2005 in “Fertility and Sterility” Some women with PCOS have CYP21 mutations and IRS1 variants, but these genetic factors are not major contributors to PCOS.
39 citations,
July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
39 citations,
January 2008 in “Journal of Endocrinology” SCF and c-Kit decrease in AGA hair follicles, possibly affecting hair pigmentation and growth.
37 citations,
April 2017 in “npj Regenerative Medicine” PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
37 citations,
June 2011 in “Journal of Cellular Biochemistry” Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.
34 citations,
May 2017 in “Lasers in Surgery and Medicine” Combining low-level light therapy and minoxidil 5% is more effective for female hair loss than using either treatment alone.
31 citations,
January 2014 in “International Journal of Trichology” The arrector pili muscle might play a role in hair loss and needs more research to understand its impact.
30 citations,
September 2004 in “Experimental Dermatology” Scalp hair follicle culture has limits for testing minoxidil's hair growth effects.
29 citations,
September 2020 in “International Journal of Molecular Sciences” The document concludes that freeze-dried platelet-rich plasma shows promise for medical use but requires standardization and further research.
28 citations,
January 2018 in “Biochemical Society Transactions” Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.
26 citations,
October 2016 in “Clinics in Dermatology” Hormonal treatments can improve acne, but they come with potential side effects and risks.
25 citations,
April 1949 in “The journal of experimental zoology” Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.
22 citations,
March 1987 in “Journal of The American Academy of Dermatology” Minoxidil prolongs cell life, slows aging, and may produce longer hairs.
20 citations,
October 2008 in “Archives of dermatological research” Angiogenin helps hair grow by stimulating cell growth and blood vessel formation.
19 citations,
May 2016 in “Clinical, cosmetic and investigational dermatology” FGF-2&D/P nanoparticles can help treat hair loss.
19 citations,
October 1996 in “Dermatologic Clinics” Dermal papilla cells are key for hair growth and could help us understand and treat hair loss.
18 citations,
December 2018 in “Expert Opinion on Biological Therapy” Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
14 citations,
October 2020 in “Scientific reports” Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.