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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The article suggests managing interferon beta therapy side effects in MS with dose adjustments, medications, and patient education.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

New effective scar treatments are urgently needed due to the current options' limited success.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.