146 citations
,
January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
96 citations
,
October 2021 in “Reproductive Sciences” Women with PCOS often experience depression and anxiety, affecting their quality of life.
50 citations
,
January 2013 in “Indian Journal of Dermatology” This review highlights the increasing association of metabolic syndrome with various dermatological conditions and suggests a link through chronic inflammation, oxidative stress, and endocrine abnormalities, yet reports no new findings.
45 citations
,
November 2024 in “International Journal of Molecular Sciences” This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.
43 citations
,
January 2016 in “Oxidative medicine and cellular longevity” This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.
39 citations
,
September 2015 in “Clinical Therapeutics” This review summarizes updated US prescribing information for teriflunomide in relapsing multiple sclerosis, highlighting its efficacy in reducing lesion activity and relapse rates but noting potential adverse effects such as headache and diarrhea.
38 citations
,
April 2020 in “IntechOpen eBooks” This review discusses the potential antidepressant effects of phenylalanine, highlighting its significant activity in laboratory studies, but reports no new clinical findings.
34 citations
,
June 2015 in “Journal of cardiovascular pharmacology and therapeutics” This article discusses the use of direct vasodilators and sympatholytic agents in hypertension management, highlighting their utility in specific cases like refractory hypertension and heart failure, but reports no new clinical results.
32 citations
,
June 2024 in “Pharmaceutics” This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.
32 citations
,
January 2022 in “International Journal of Molecular Sciences” This review discusses the impact of melatonin and its metabolites on skin aging, summarizing how they may serve as "aging neutralizers" through their anti-oxidative and anti-inflammatory properties, but reports no new clinical results.
24 citations
,
July 2019 in “Reproductive Medicine and Biology” This review discusses the classification and treatment of ejaculatory dysfunction, outlining both pharmacotherapy and behavioral therapy as primary interventions, but does not present new clinical findings.
21 citations
,
November 2021 in “Biomolecules” This review compiles information on traditional uses, phytoconstituents, and biological activities of Eclipta prostrata but reports no new experimental results; the authors call for more studies to understand its pharmacological mechanisms.
20 citations
,
June 2022 in “Molecules” This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.
20 citations
,
February 2022 in “British Journal of Dermatology” This study found that people with alopecia areata have higher rates of depression and anxiety, leading to increased mental health treatment burden, more time off work, and higher unemployment compared to the general population.
20 citations
,
January 2017 in “Genetica” This study suggests that the methylation degree of HOXC8 exon 1 in the hair follicle may influence cashmere fiber growth in Liaoning cashmere goats.
18 citations
,
December 2021 in “Foods” This study explores the potential of seaweeds as a source of bioactive compounds for food, cosmetics, and medical applications, while highlighting concerns about toxic element accumulation and suggesting purification and nanoencapsulation techniques to enhance safety and stability.
17 citations
,
September 2024 in “Molecules” This literature review compiles and analyzes current research on turmeric essential oil's active compounds, reporting their potential therapeutic applications across various medical conditions due to their unique pharmacological profiles and absence of toxicity.
15 citations
,
January 2023 in “Journal of Translational Autoimmunity” This review examines recent research on melatonin's biochemical activities, particularly in skin health, but reports no new clinical results and emphasizes its potential for future medical applications.
15 citations
,
April 2008 in “Headache” This review discusses the complex relationship between migraine and psychiatric disorders, highlighting the need for individualized treatment plans but reports no new clinical results.
13 citations
,
April 2002 in “International Journal of Toxicology” This review discusses the use of human and animal-derived placental and umbilical extracts in cosmetics, highlighting insufficient data to establish their safety and recommending they should not have metabolic or endocrine activity.
10 citations
,
July 2022 in “BMC Biology” This review discusses how sex-limited chromosomes can affect non-reproductive traits in various sex determination systems and reports no new empirical results.
9 citations
,
March 2022 in “Antioxidants” This review summarized and classified 32 approved synthetic and natural-identical antioxidants, examining their regulatory status, safety, pharmacological properties, and effectiveness on human health, aiming to clarify their antioxidant actions and encourage further research in the field.
6 citations
,
August 2024 in “Viruses” This review reported that despite identifying over 200 symptoms associated with long COVID, significant gaps and controversies remain in understanding its diagnosis, pathophysiology, risk factors, and the impact of viral strains and vaccination.
6 citations
,
April 2022 in “Biomedicine & pharmacotherapy” This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.
6 citations
,
April 2021 in “NAR Genomics and Bioinformatics” This study found extensive co-evolution of polyglutamine repeat lengths in neural protein clusters, highlighting their potential role in neurocognitive variation and neuropsychiatric disease development.
4 citations
,
August 2025 in “Journal of Food Science” This review highlights that Tremella fuciformis polysaccharide exhibits various bioactivities, such as antioxidant and immune-modulating effects, and explores its potential applications in food, pharmaceutical, and cosmetic industries.
4 citations
,
January 2025 in “International Journal of Molecular Sciences” This study found that progesterone and its metabolite, allopregnanolone, provided anti-anxiety and anti-depressive effects in female mice, potentially independent of nuclear progestin receptors but requiring 5α-reduction and estradiol's influence on brain-derived neurotrophic factor.
4 citations
,
November 2021 in “Molecular Medicine Reports” In this study on a mouse model of vitiligo, NB-UVB/ADSC combination therapy improved oxidative stress and calcium homeostasis, but the protective effect was reversed by inhibiting Nr2 signaling.
4 citations
,
April 2004 in “Medical veritas” This journal serves as a platform for diverse perspectives on vaccine-related issues, but the abstract itself reports no new scientific findings.
3 citations
,
September 2025 in “ChemMedChem” This review highlights the inadequacy of the "specificity paradigm" in drug design for complex diseases like Alzheimer's and cancer, suggesting a shift toward developing multitarget drugs to improve treatment efficacy by interacting with multiple targets through various mechanisms.