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This case report highlights a novel NR5A1 gene variant associated with a severe 46,XY disorder of sex development, stressing the importance of genetic screening in similar cases.

This review discusses the use of zebrafish larvae as an alternative model for studying ototoxicity, facilitating large-scale screening for otoprotective compounds, but reports no new clinical results.

This review systematically assembles recent insights into the use of hair follicle neural crest stem cells and their exosomes for peripheral nerve injury repair, highlighting molecular mechanisms and possible translational applications, with comprehensive tables and diagrams summarizing existing literature.

This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.

This study found that using human induced pluripotent stem cells (iPSC) carrying the causal mutation of Epidermolysis Bullosa simplex provides a robust model for understanding its molecular mechanisms and testing potential therapeutic targets.

This source critically examines Bruce Ames's influential contributions to biochemistry, particularly his theories on oxidative stress and mitochondrial DNA damage in aging, while acknowledging current challenges to his work and highlighting his lasting impact on the fields of mutagen screening and public health.

This study suggests that two approved drugs may inhibit the SARS-CoV-2 helicase based on significant activity in laboratory models, offering hope for potential COVID-19 treatments.

This review discusses how recent advancements in computational and lab-based methods have enhanced peptide drug discovery, noting the efficiency and cost benefits over traditional approaches and the potential for targeting difficult protein interactions, including protein degradation using proteolysis-targeting chimeras.

This study identified a thiazolidine dione derivative as a potential inhibitor of 15-PGDH that may enhance prostaglandin activity in hair follicles, suggesting its use to support hair regrowth treatments.

In this study, researchers validated a computational workflow for repurposing non-antibacterial drugs as antibacterial agents and highlighted daprodustat, combined with an efflux pump inhibitor, as a promising strategy against bacterial pathogens.

In this review, the authors systematically summarize recent advances in using hair follicle neural crest stem cells and their exosomes for repairing peripheral nerve injuries, focusing on mechanisms and applications derived from existing literature, although it does not include primary experimental data.

Children need early diagnosis and treatment for iron-deficiency anemia to prevent learning problems and promote health.

This study found that ferulic acid effectively stabilized vitamins C and E in a topical solution, doubling skin photoprotection against solar-simulated irradiation, which may help in preventing photoaging and skin cancer.

This review discusses nonclassical 21-hydroxylase deficiency as the most common autosomal recessive disorder in humans and highlights the effectiveness of glucocorticoid treatment in reversing related symptoms.

This review describes the clinical presentation, diagnosis, and management of adrenomyeloneuropathy, including rehabilitative therapies and spasticity management, and reports no new clinical results.

This review discusses the epidemiology, clinical manifestations, and pathogenesis of autoimmune skin diseases and their associations with thyroid diseases, reporting no new clinical results.

This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.

In this study, the researchers report that a modified epimorphin-derived peptide shows potential for hair follicle regeneration, especially when used with 1% minoxidil in mice.

This study found that extracellular vesicles derived from 3D cultures of cervical cancer cells have small RNA profiles more similar to those in patient plasma than those from 2D cultures.

Antisense oligonucleotides show promise for treating Myotonic Dystrophy type I.

This study highlights the increasing prevalence of hyperuricemia as a metabolic and vascular disorder due to lifestyle changes, emphasizing the need for early diagnosis of prehyperuricemia to prevent related non-communicable diseases and complications.

This discussion reviews the shift in pharmaceutical strategy towards evidence-based and structure-guided drug development, highlighting ongoing challenges and efforts in computer-aided drug design without presenting new clinical results.

This narrative review explores the failure of fludalanine as an orally active antibiotic and highlights valuable insights into problem-solving strategies in drug discovery, without reporting new clinical results.

This study suggests that activating the hexosamine pathway may enhance skin homeostasis, potentially increasing hair follicle stem cells and modifying extracellular matrix components like hyaluronic acid in vitro.

This review discusses the preventable nature of many cancers due to modifiable risk factors and emphasizes the importance of preventive oncology in reducing the global cancer burden; it reports no new clinical results.

This study demonstrated the development of high-density protein microarrays allowing for antibody binding characterization and serum profiling from patients with autoimmune diseases, suggesting potential for diagnostic marker discovery.

This study identifies five compounds, including gemcitabine and methylene blue, that inhibit SADS-CoV and suggests their potential for developing antiviral drugs against future outbreaks.

This study explored the anti-hair loss potential of plant extracts like licorice, salvia miltiorrhiza, and others, finding they increased ALP and β-catenin expression and reduced TGF-β1 and IL-6 in human dermal papilla cells without cytotoxicity.

In this study, researchers developed a sensitive assay to measure the inhibition of steroid 5-α reductase (5AR) by chemicals like finasteride and dutasteride, revealing species-specific differences in inhibitor efficacy between human and fish cell lines.

Some natural compounds might help hair grow.