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This study found that hydroalcoholic extracts of Trigonella foenum-graecum L. seeds were rich in bioactive phytochemicals and demonstrated potential therapeutic properties against dandruff, alopecia, and oxidative stress through molecular docking analysis of key constituents such as diosgenin, kaempferol, and quercetin.

This study discovered a potential new 5α-reductase type II inhibitor with higher predicted activity than finasteride, suggesting it as a promising candidate for treating benign prostatic hyperplasia.

This molecular docking study reported that danoprevir, remdesivir, and saridegib exhibit stronger binding affinities to the main protease of SARS-CoV-2 than the control, suggesting their potential as inhibitors of the virus's replication process.

In this study using a virtual screening approach, eriocitrin and silymarin were identified as potent flavonoid compounds that strongly and stably interacted with 5α-reductase type II, suggesting potential development as novel treatments for androgenic alopecia.

This study found that several small molecule peptides based on thymosin β4 significantly promoted cell proliferation related to wound healing, angiogenesis, and hair growth more effectively than established positive controls.

This study identified nine compounds that activate Wnt signaling, with aminoacridine and proflavine especially promoting hair and nail regeneration in mouse models, highlighting new therapeutic candidates from existing FDA-approved and natural compounds.

In this study, researchers identified nine FDA-approved drugs that activate the Wnt signaling pathway, with Aminoacridine, especially when combined with Minoxidil, showing promising effects on hair and nail growth in mice, suggesting potential treatments for hair and nail loss pending further clinical trials.

This study optimized a screening assay to identify molecules that inhibit or enhance TRPM5 ion channel activity, which may have implications for treating dysfunctions linked to cardiac arrhythmias and diabetes.

This study presents a rapid method for detecting multiple xenobiotics in urine, effectively identifying 45 compounds banned in sports with detection limits below WADA's performance levels.

This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.

This article reviews genetic and phenotypic aspects of androgen insensitivity syndromes, emphasizing the diversity of mutations that complicates molecular screening and the importance of genotype-phenotype correlations.

In this study, in silico screening and molecular simulations identified β-sitosterol and brassicasterol as stable potential inhibitors of 5α-reductase1, suggesting they could be explored for androgenic alopecia treatment.

In this study, phytochemical analysis and molecular docking suggested that bioactive compounds in several Ayurvedic herbs may interact persistently with hair growth and antifungal protein targets, indicating potential as plant-based treatments for dandruff and hair loss.

This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.

This review discusses Omenn syndrome, a form of severe combined immunodeficiency, highlighting its immunopathology and genetic defects without presenting new clinical results.

This study concluded that neither basal nor ACTH-stimulated 17-OHP concentrations effectively indicate carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic women, recommending molecular analysis of the CYP21 gene for reliable screening.

This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.

This study used machine learning to develop classifiers for identifying effective inhibitors of 5α-reductase isozyme 2, achieving high performance in distinguishing potent from weak inhibitors.

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

This study suggests that three mushroom-derived bioactive compounds, Zhankuic acid A, Sterenin M, and Melleolide K, may effectively inhibit SRD5A2 and stabilize its interaction, indicating potential for treating androgenic alopecia.

This study used molecular docking to identify stiripentol as a potential new inhibitor of the SRD5A2 enzyme, which is targeted for treating androgen-related diseases; however, in vivo trials are needed to validate its efficacy.

This study identified 29 Moroccan medicinal plants containing compounds that may act as natural inhibitors of SARS-CoV-2 based on molecular docking and in-silico analyses.

This study identified 674 differentially expressed proteins in the skin tissues of male and female Chinese merino sheep, suggesting gender-specific molecular mechanisms that may affect wool traits.

This study suggests that hesperidin may regulate pathways in hair follicle cells to help mitigate hair loss, revealing molecular mechanisms of nitric oxide donor-mediated hair follicle protection.

This study found that humulen, a phytoconstituent of Cyperus Rotundus Linn., showed the highest binding affinity in molecular docking with the 5 α reductase enzyme, suggesting potential anti-androgenic effects for hirsutism treatment.

This study developed a deep learning-based method that identified 3,620,516 potential drug-disease associations, suggesting a promising tool for large-scale virtual screening in drug research.

In this study, researchers reported that specific gene polymorphisms in Jiangnan cashmere goats, particularly SNPs in the HOXC13 and WNT4 genes, were significantly associated with key economic traits like birth weight and yearling weight, providing molecular markers for breeding and enhancing economic trait stability.

This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.

This study identified several compounds, including Pictilisib and Nimorazole, that may have higher binding affinity for SARS-CoV-2 main protease than existing inhibitors, potentially offering new treatment alternatives for Covid-19.

This study demonstrated that a computational screening process can identify existing drugs and natural compounds with potential anti-COVID-19 activity, highlighting some candidates for further experimental validation.