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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

New effective scar treatments are urgently needed due to the current options' limited success.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Latanoprost can make eyelashes longer, thicker, and darker.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Use minoxidil for hair loss treatment; assess results after 6 months.

Finasteride effectively blocks enzyme causing male pattern baldness.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Liposomes could improve how skin care products work but are costly and not very stable.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Feather growth and regeneration involve complex patterns, stem cells, and evolutionary insights.

Mannosylerythritol lipids are good for skin and hair care products.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Certain mice without specific receptors or mast cells don't lose hair from stress.