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Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

Treatments for permanent hair loss from scarring aim to stop further loss, not regrow hair, and vary by condition, with partial success common.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Lichen planopilaris is a chronic, scarring hair loss condition with no definitive cure, requiring accurate diagnosis and treatment to manage symptoms.

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

Wool follicles are complex, involving interactions between different cell types and structures.

Trichoscopy helps diagnose and monitor alopecia areata by looking at a combination of specific hair and scalp features.

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

Some drugs can cause hair loss, change hair color and shape, or increase hair growth, and treatment may involve stopping the drug or using specific hair growth treatments.

Treatments for melanin disorders exist, but more effective options needed.

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

Liver transplantation is a viable option for children with propionic acidemia, improving quality of life and diet, but does not remove all risks and long-term brain outcomes are uncertain.

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

Targeting the skin's endocannabinoid system could help treat skin disorders.

CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.

Blue light promotes hair growth by interacting with specific receptors in hair follicles.

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Toxic Shock Syndrome cases increased due to new factors, but decreased with public health measures and changes in tampon use.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

The document concludes that early recognition and treatment of primary cicatricial alopecia is crucial to prevent permanent hair loss.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

The 308-nm excimer laser is a promising treatment for vitiligo with varying success and mild side effects.

Vitiligo causes white skin patches and is linked to autoimmune issues.