122 citations
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January 2006 in “Molecular & Cellular Proteomics” This study found that keratin and other hair proteins in humans are extensively modified posttranslationally, which helps explain the structural characteristics of mature hair.
1 citations
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March 2019 in “International Journal of Molecular Medicine” This study demonstrated that hair follicle cells can be induced to differentiate into cardiomyocyte-like cells in vitro, exhibiting characteristics and spontaneous beating typical of cardiac muscle, without genetic modification.
In this study, deleting the -catenin gene in vitamin D receptor-null mice did not prevent tumor development, suggesting -catenin's predicted protective role was not observed.
February 2024 in “Deleted Journal” This case study in a Labrador dog diagnosed with cutaneous lymphoma reports that treatment using the modified Wisconsin Madison protocol led to an uneventful recovery, despite the occurrence of vincristine-associated ileus, which was successfully treated with neostigmine.
October 2025 in “Burns & Trauma” This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.
44 citations
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February 2023 in “Cell” In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
March 2026 in “International Wound Journal” This study evaluated the credibility of YouTube videos on exosome therapy, finding that despite promising preclinical results for wound healing, videos mostly focus on cosmetic applications and generally score low on educational quality, with doctor-made videos rating higher.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reviews the effectiveness and safety of finasteride and dutasteride for treating androgenetic alopecia, highlighting that dutasteride reduces DHT more deeply than finasteride, with genetic factors influencing patient response and both drugs being evidence-supported options for men and women.
May 2001 in “Journal of Investigative Dermatology” In this study, Maas-Szabowski and Szabowski revealed that c-Jun and JunB transcription factors, as well as granulocyte macrophage-colony stimulating factor, regulate human keratinocyte growth and differentiation in fibroblast–keratinocyte interactions.
11 citations
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May 2012 in “Genesis” This study in mutant mice found that Bmpr2 and Acvr2a are individually redundant, but together essential for normal hair follicle development, with their reduction causing rapid hair cycling and graying.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” This study found that increased PHGDH expression in mice led to earlier melanin and melanocyte presence in hair follicles but did not induce cancer.
24 citations
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November 2023 in “Nature” In this study, researchers demonstrated that the expression of the oncogene SmoM2 leads to basal cell carcinoma in the ear epidermis of mice but not in the back skin, with differences in susceptibility linked to the composition of the extracellular matrix.
10 citations
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July 2019 in “Advances in Wound Care” This study suggests that Flightless I may inhibit the activation of epidermal stem cells during wound repair by disrupting Wnt/β-catenin signaling, potentially delaying wound reepithelialization.
April 2016 in “Journal of Investigative Dermatology” This study found that a newly developed peptide, FOL-005, significantly inhibited hair growth and counteracted minoxidil's effects in organ-cultured human male scalp skin and mouse models, without apparent toxicity.
61 citations
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January 2011 in “PloS one” In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.
16 citations
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November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study found that intramuscular anti-IFN-γ significantly stabilized and promoted hair regrowth in alopecia areata patients with patchy, progressive hair loss, whereas those with total baldness showed more limited improvement.
8 citations
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February 2014 in “Stem cells translational medicine” This study found that human mesenchymal stem cells overexpressing JAM-A improved hair follicle structure and hair formation in mice by reducing abnormalities such as curved and zigzagged follicles.
7 citations
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January 2011 Collagen XVIII is crucial for maintaining tissue structure and function in the brain, kidneys, and hair.
5 citations
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February 1997 in “Bioorganic & Medicinal Chemistry” This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.
4 citations
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February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” In this study, only Vdr-knockout rats showed both abnormal skin formation and alopecia, which may provide insights into vitamin D receptor function and its role in the hair growth cycle.
1 citations
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October 2022 in “Scientific reports” This study found that nestin-expressing progenitor cells, capable of becoming ORS keratinocytes, are present in both developing and adult mouse hair follicles.
June 2022 in “Research Square (Research Square)” This study revealed that nestin-expressing progenitor cells capable of becoming ORS keratinocytes are present during both hair follicle development and in adult hair follicles.
June 2020 in “Nihon Ika Daigaku Igakkai Zasshi” This study found that aPKCλ, but not aPKCζ, plays a critical role in maintaining hair follicle stem cell populations and promoting wound healing in the epidermis.
July 2025 in “Journal of Investigative Dermatology” TGF-β signaling is essential for hair follicle regeneration during wound healing.
63 citations
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August 2022 in “Diagnostics” This review discusses hirsutism in women with PCOS who present with normal androgen levels and highlights diagnostic challenges, reporting no new clinical findings.
14 citations
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January 2023 in “Nature Immunology” iNKT cells help develop and maintain healthy skin in young mice.
November 2023 in “Journal of the Taiwan Institute of Chemical Engineers” Scientists made nanoparticles from human hair proteins to improve drug delivery.
July 2002 in “Journal of cosmetic dermatology” This article reviews various causes and treatments for hair loss and reports no new clinical findings; androgenetic alopecia and surgical options like hair transplantation are highlighted.
343 citations
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March 2016 in “Nature Communications” This study found that IL-17A-producing γδ T cells play a key role in bone fracture healing by promoting bone formation, with deficiencies leading to impaired repair in mice.