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In this study, MSC-derived magnetic nanovesicles combined with a magnetic field increased skin retention and accelerated hair follicle growth in a mouse model of hair regeneration.

In this study, a pH-responsive microneedle patch was developed, showing potential in rat models for treating spinal cord injuries by reducing inflammation, promoting nerve regeneration, and supporting neurogenesis, which contributed to improved motor and neurological recovery.

Microneedling combined with other treatments significantly improves hair growth in people with hair loss and is safe.

This chapter reviews the combined use of platelet-rich plasma and microneedling for cosmetic enhancement but reports no clinical results; the authors highlight existing uses and suggest potential synergistic benefits in dermatology.

This review reports significant advancements in plastic surgery using stem cell therapies for aesthetic and reconstructive applications, including grafting and wound healing, though it underscores the need for continued research to address regulatory, ethical, and standardization issues.

This scoping review found that microneedle patches loaded with exosomes, primarily derived from mesenchymal stem cells, show promising potential for delivering exosome therapies to treat non-cicatricial alopecia, suggesting new directions for enhancing hair follicle regeneration.

In this study, researchers developed a biodegradable microneedle made of hyaluronic acid, intended to enhance drug delivery through the skin's stratum corneum and potentially promote hair growth by overcoming the skin's barrier function in alopecia treatment.

This study found that minoxidil and ranolazine, individually and in combination, reduced cellular invasiveness in hypoxic triple-negative breast cancer cell lines, suggesting potential anti-metastatic effects at clinically relevant doses.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.

This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.

In this mouse study, researchers found that nanoparticles loaded with umbilical cord-derived stem cell membranes and minoxidil enhanced hair growth by improving drug solubility and transdermal delivery, increasing VEGF, IGF-1, MKI67, and CTNNB protein levels in skin tissue compared to regular minoxidil.

This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.

In this study, N-MXD (minoxidil nanoparticles) was shown to deliver more drug into hair bulbs and enhance IGF-1 and VEGF levels more effectively than commercial formulations, resulting in higher therapeutic efficiency for hair growth in C57BL/6 mice.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.

New microneedle method improves hair regrowth treatment delivery.

This review discusses the applications and potential of microneedles loaded with extracellular vesicles for tissue regenerative repair and disease diagnosis, but does not report new experimental findings.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.

This review highlights recent advancements in microneedle technology, noting its ability to enhance transdermal drug delivery, biosensing, cancer treatment, and skin disease repair, while emphasizing its potential for improving patient compliance and reducing side effects.

A new, quick method accurately detects minoxidil in drugs and cosmetics.

This article discusses the potential of novel microneedle transdermal systems for enhanced drug and vaccine delivery through the skin, but reports no clinical results and emphasizes ongoing trials.

This study concluded that Trilayer Dissolving Microneedles show promise in enhancing Minoxidil delivery for treating alopecia areata by improving its bioavailability and reducing side effects.

This study highlights the clinical potential of microneedles as an innovative transdermal drug delivery system for treating various skin diseases with minimal pain and high patient compliance.

This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.

This research highlights the potential of non-coding RNAs as biomarkers and therapeutic targets in dermatology, while experimental studies on a unique GVM case suggest CCM2L may modulate disease severity, advancing understanding of genetic mechanisms in rare skin disorders.

In animal studies, this research found that minoxidil-loaded air-pocket microneedles improved hair loss treatment efficiency compared to topical application, while effectively sealing punctured skin openings.

This review highlights the application of microneedle technology as a promising advancement in psoriasis management, focusing on its roles in enhanced transdermal drug delivery and minimally invasive biomarker monitoring, while also discussing current challenges and future research directions.

In this study, minoxidil nanoparticles significantly increased hair growth rate in C57BL/6 mice compared to traditional minoxidil, suggesting enhanced effectiveness and potential as a new formulation.

This study found that nanovesicles derived from ReNcell VM cells promoted hair growth in mice by activating the Wnt/β-catenin signaling pathway, suggesting they may serve as an alternative to extracellular vesicles for hair growth therapy.

This study confirmed that microneedle therapy systems (MTS) significantly improve hair growth and skin conditions, including acne and acne scars, without serious side effects.