11 citations
,
May 2010 in “Journal of the South African Veterinary Association” This case report describes how a treatment with mycophenolate mofetil and prednisone may be effective in managing autoimmune subepidermal blistering dermatosis in dogs while allowing for steroid reduction.
10 citations
,
August 2024 in “Clinical Cosmetic and Investigational Dermatology” This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.
10 citations
,
November 2022 in “Protein & Cell” In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.
10 citations
,
March 2022 in “Communications biology” In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.
9 citations
,
July 2020 in “Experimental Dermatology” This review emphasizes the potential of repurposing topical L-thyroxine for skin ulcers and telogen effluvium and highlights the need for further exploration of its use in dermatology.
9 citations
,
April 2019 in “Molecules” This study found that a blackcurrant extract with phytoestrogen activity increased hair number and stem cell marker expression in a menopausal rat model, suggesting a potential benefit for hair loss.
9 citations
,
February 2019 in “BMC cancer” This study found that M30 may protect against cyclophosphamide-induced alopecia in mice by enhancing hair growth and preventing abnormal hair, suggesting its potential as a treatment.
9 citations
,
April 2016 in “Cutaneous and ocular toxicology” This study found that Alpha Lipoic Acid may help reduce cigarette smoke-induced skin damage in rats by improving collagen structure and reducing markers of oxidative stress.
9 citations
,
October 2008 in “Mutation research” This article discusses the genomic and postgenomic changes in chronic degenerative diseases and cardiovascular and skin disease contexts, highlighting potential modulation through diet and pharmacological interventions without presenting new experimental results.
8 citations
,
June 2022 in “Frontiers in bioengineering and biotechnology” This study found that a collagen patch made with fibroblast-derived extracellular matrix (fdECM) extracted from human lung fibroblasts enhanced wound healing by promoting wound contraction, angiogenesis, and skin remodeling in full-thickness skin wound models, including those with diabetic ulcers.
8 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This study reported that exogenous R-spondin-1 can restore hair follicle neogenesis in adult mouse cells, highlighting differences in gene expression and signaling pathways between fetal and adult dermal papilla cells.
7 citations
,
June 2024 in “Communications Medicine” In this study, researchers analyzed spaceflight data from various sources and found that skin issues during spaceflight are linked to DNA damage, mitochondrial dysregulation, and gene alterations, while also highlighting the skin's adaptability post-flight.
7 citations
,
January 2021 in “Evidence-based complementary and alternative medicine” This study suggests that porphyra-334 may have antiaging properties, promoting collagen synthesis, improving periorbital wrinkles, and supporting hair follicle growth through gene regulation.
7 citations
,
October 2018 in “BMC genomics” This study reveals that β-catenin and retinoic acid are key regulators in the gene networks controlling the fate of skin appendages, such as scales and feathers.
6 citations
,
January 2023 in “npj regenerative medicine” This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.
6 citations
,
May 2022 in “Aging” This study found that Si Jun Zi Tang may have anti-aging effects in mice, linked to inhibition of the PI3K-AKT and P38 MAPK signaling pathways.
6 citations
,
September 2021 in “AESTHETIC OROFACIAL SCIENCE” This review discusses the cost-effectiveness and potential benefits of platelet-rich plasma for facial dermal rejuvenation but reports no new clinical results.
6 citations
,
June 2021 in “Developmental biology” This study found that dermal EZH2 plays a crucial role in controlling fibroblast differentiation by regulating Wnt/β-catenin and retinoic acid signaling during skin development.
6 citations
,
September 2015 in “Journal of Investigative Dermatology” This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.
6 citations
,
January 2010 in “Springer eBooks” SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.
5 citations
,
October 2024 in “International Journal of Biological Sciences” This study found that a specific fragment of AIMP1, secreted by hair follicle stem cells, activated dermal papilla cells, leading to enhanced hair regrowth and maintenance in mice.
5 citations
,
October 2023 in “Aging” This study found that activating SHH signaling in EPCs enhances angiogenesis to aid in healing pressure ulcers through the PI3K/AKT/eNOS pathway, indicating SHH signaling as a potential target for treatment.
5 citations
,
January 2021 in “iScience” Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.
4 citations
,
January 2026 in “Cell Discovery” This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.
4 citations
,
May 2025 in “npj Parkinson s Disease” This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms.
4 citations
,
June 2021 in “Dermatology” This study validated the HS 3D-SeboSkin model as a reliable tool for preclinical research, effectively preserving the structure and biomarker expression of lesional and perilesional HS skin ex vivo.
4 citations
,
February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
4 citations
,
May 2020 in “PLOS ONE” This study found that ingenol mebutate treatment led to gene expression changes in actinic keratoses, with complete lesion clearance in 40% of patients and identified genetic markers potentially predicting treatment response.
4 citations
,
September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” This study found that CD2 could be a potential new therapeutic target for treating patchy-type alopecia areata, suggesting the need for further research into its role.
4 citations
,
November 2017 in “Scientific Reports” This study compiled an archive of 684 genes associated with monogenic hair disorders, identifying previously unrecognized components of Hippo signaling and proposing a new biologically-grounded disease taxonomy.