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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Tempol is safe and may prevent hair loss from brain radiotherapy.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Applying a special compound can promote hair growth without harmful side effects.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Iranian veterans exposed to sulfur mustard suffer from long-term skin itching and eye damage, with some risk of skin cancer and ongoing management challenges.

Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Memantine may slightly improve memory in people with Down syndrome, but more research is needed.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.