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In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.

Deleting Crif1 in mouse skin disrupts skin balance and hair growth.

In this study, Saw Palmetto at a physiological dose partially inhibited 5-α-reductase and improved hormonal balance, inflammation, and mitochondrial function, with synergy observed when combined with Lycopene, L-Arginine, and Astaxanthin, enhancing male prostatic and endocrine health without endocrine side effects.

This study reported that Saw Palmetto, at a physiological dose, partially inhibits 5-alpha-reductase and, when combined with Lycopene, L-Arginine, and Astaxanthin, demonstrates a synergistic effect in restoring hormonal balance, reducing inflammation, and improving hair density, urinary flow, and oxidative biomarkers in related male health conditions.

This article reviews the roles and synthesis of essential long-chain fatty acids in the body and reports no new research findings; it emphasizes the importance of dietary sources for these lipids.

This ex vivo study reported that melatonin significantly improved certain aging biomarkers in aged human skin, including reduced mTORC1 activity, increased fibrillin-1, and enhanced collagen and elastic fiber organization, though other key biomarkers remained unchanged.

In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.

This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

This review evaluates the anti-aging properties of TSG from He shou wu, finding it may protect against age-related diseases through multiple mechanisms, though further research is needed for clinical application.

This research discusses the shift in cosmetic dermatology towards integrating regenerative medicine, AI, and personalized care, highlighting their potential to improve aesthetic outcomes and skin function while considering ethical and regulatory challenges.

This study found that 3-hydroxypropionic acid improved the function of hair follicle cells under oxidative stress, suggesting potential as a treatment for stress-related hair loss.

This review synthesizes recent molecular and preclinical advances in alopecia areata and androgenetic alopecia, highlighting how interventions targeting specific intracellular signaling pathways and utilizing stem cell technologies can support precision regrowth and structural follicle reconstruction.

In this study involving ICR mice, researchers found that Korean red pine bark extract improved cognitive functions impaired by TMT through mechanisms like antioxidant system protection, cholinergic and synaptic support, mitochondrial regulation, and reduction of neuro-inflammation and apoptosis.

This study found that high exposure to air pollutants like SO2, NO, NO2, NOx, and PM2.5 was linked to a significantly increased risk of developing PCOS in women.

This study observed that mice with a whole-body deficiency of Cystathionine-β-synthase developed severe hyperhomocysteinemia and related mild symptoms without increased mortality, indicating HHCy may not directly cause end organ damage.

This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.

This review discusses the impact of melatonin and its metabolites on skin aging, summarizing how they may serve as "aging neutralizers" through their anti-oxidative and anti-inflammatory properties, but reports no new clinical results.

This review examines melatonin's potential effects on human skin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.

This article discusses the potential health risks associated with long-term use of finasteride and dutasteride for prostate and hair loss treatments, suggesting risks may include non-alcoholic fatty liver disease, insulin resistance, type 2 diabetes, and other metabolic issues.

In this review, researchers explored how PGC-1α might improve aged skin barrier function by influencing mitochondrial function and reducing inflammation, factors that are linked to epidermal health during aging.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This review discusses the fundamental hallmarks of aging as they relate to skin aging and highlights the prominent roles of oxidative damage and the extracellular matrix in photoaging, reporting no new results.

This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.

In this exploratory in vitro study, treatment with spermidine increased cell viability and altered gene expression in human epidermal keratinocytes, suggesting potential benefits to cellular health and function, though effects on mitochondrial markers were not significant.

In this study, researchers developed ionizable coenzyme Q10-engineered lipid/fiber microplexes that restored mitochondrial-ribosomal function and enhanced mRNA translation in senescent cells, leading to increased hair follicle density and bone formation in mouse models compared to conventional lipid nanoparticles.

In this literature review, it was reported that mental health disorders may both contribute to and be exacerbated by various types of hair loss, and an interdisciplinary treatment model is recommended for effective diagnosis and patient care.

In this study, the researchers found that Astragalus sinicus extracts improved wound healing, reduced oxidative stress, and activated crucial signaling pathways in dermal papilla cells damaged by dihydrotestosterone, suggesting it may be a promising ingredient for hair loss treatment.

This study explored the effects of DPP, a 15-PGDH inhibitor, on human follicle dermal papilla cells damaged by dihydrotestosterone and observed that DPP enhanced wound healing, reduced reactive oxygen species, and increased hair growth in ex vivo human hair follicle cultures.

This review discusses the implementation and mechanisms of photobiomodulation therapy in various medical fields, including ophthalmology, and reports no new clinical results.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.