110 citations
,
April 2020 in “Advances in Wound Care” This review discusses recent advancements in nanotechnology-based treatments for chronic wound healing in diabetic models, noting that despite promising results, these innovations have yet to translate into widely available commercial products.
70 citations
,
May 2023 in “Molecules” This source reviews recent research on Ginkgo biloba, highlighting its medicinal benefits due to compounds in the leaves and concerns over toxic alkylphenols in seeds. It also discusses patents for its food production uses and ongoing studies on toxicity and drug interactions.
56 citations
,
January 2023 in “Genes & Diseases” This study discusses a hypothesis for repurposing non-cancer drugs and combining micronutrients to target cancer and cancer stem cells with fewer side effects, suggesting a potential new approach for more effective cancer therapy.
54 citations
,
January 2023 in “Signal Transduction and Targeted Therapy” This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
49 citations
,
December 2022 in “Pharmacological Reviews” This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.
48 citations
,
May 2019 in “Genome Biology” This study identified genetic, biological, and technical factors that influence circRNA expression in the human brain, connecting these factors to potential genetic risk for diseases like schizophrenia and type II diabetes.
45 citations
,
August 2018 in “Stem Cells International” This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.
44 citations
,
July 2020 in “Stem Cell Research & Therapy” This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.
43 citations
,
September 2021 in “Nutrients” This review discusses the vast potential uses of persimmon beyond its dietary benefits, including applications in sustainability and new product development, but reports no new clinical outcomes.
42 citations
,
July 2017 in “Molecular therapy” This study found that applying a tocotrienol-rich phytochemical topically induced hair follicle development in adult mice, revealing a new epidermal pathway involving E-cadherin and β-catenin.
39 citations
,
August 2022 in “Pharmaceutics” This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.
39 citations
,
April 2019 in “The journal of immunology/The Journal of immunology” This study found that Malt1, particularly its protease activity, plays a crucial role in maintaining Treg cell function and homeostasis, with its inactivation leading to autoimmune diseases and altered immune responses in mice.
37 citations
,
August 2024 in “Current Issues in Molecular Biology” This review summarizes recent findings on keratins 6, 16, and 17, highlighting their role in keratinocyte behavior and nuclear functions, and discusses their potential as biomarkers for various skin pathologies, including damage, inflammation, and cancer, rather than in healthy skin.
36 citations
,
August 2022 in “Molecular Therapy — Nucleic Acids” This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.
33 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” In this study, researchers found that during zebrafish telencephalon regeneration, the lesioned hemisphere showed distinct gene expression changes and activated Wnt/β-catenin signaling early after injury, suggesting this pathway's significant role in recovery.
31 citations
,
June 2022 in “Stem Cell Research & Therapy” This study found that umbilical cord-derived CD146+ MSCs showed a stronger ability to improve ovarian function and modulate immune responses in a mouse model of premature ovarian failure compared to CD146- MSCs, though both subpopulations effectively repaired reproductive ability.
31 citations
,
August 2021 in “Stem Cell Research & Therapy” This review examines the life cycle, biomarkers, and functions of hair follicle stem cells, emphasizing their role in hair loss therapy and other skin and hair disorders, but reports no new clinical results.
31 citations
,
March 2016 in “Journal of Investigative Dermatology” AKR1B10 enzyme may cause keloid scars and could be a treatment target.
29 citations
,
December 2021 in “Pharmaceutics” This review discusses the use of phospholipid soft vesicle carriers to improve the delivery and therapeutic outcomes of topical treatments for various skin conditions, but reports no new clinical results.
26 citations
,
November 2022 in “European journal of medical research” This review discusses the potential of nanoparticles to modify angiogenesis processes for therapeutic applications and reports no new clinical results, highlighting challenges and future prospects in treating angiogenesis-related diseases.
25 citations
,
February 2023 in “Aesthetic Surgery Journal” This review concludes that current clinical and preclinical evidence does not indicate oncologic safety concerns linked to photobiomodulation therapy for skin rejuvenation, including no clear evidence of increased cancer risk.
24 citations
,
March 2024 in “Antioxidants” In this review, researchers reported that cinnamon and ginger supplementation may benefit PCOS patients by improving hormonal status, lipid profiles, obesity, and insulin resistance through oxidative stress and inflammation reduction.
24 citations
,
July 2023 in “Journal of Functional Biomaterials” This review evaluates recent advances from 2016 to 2022 in the use of microbubbles and nanobubbles, highlighting their potential for safer diagnostic and therapeutic applications in radiology and medicine without the side effects associated with traditional methods.
24 citations
,
May 2022 in “BMC Veterinary Research” This study identified key mRNAs and lncRNAs, along with related pathways, that play potentially important roles in hair follicle development and cycling in cashmere goats.
24 citations
,
March 2020 in “Cells” This review provides an overview of natural product-derived small molecule modulators of the Wnt signaling pathway, exploring their potential as therapeutic agents for tissue regeneration and cancer treatment.
21 citations
,
August 2024 in “Journal of Clinical Medicine” This review highlights that malnutrition, including deficiencies in proteins and micronutrients, may exacerbate allergic conditions like dermatitis and asthma by promoting inflammation, while adequate micronutrient intake supports regulatory immune responses.
20 citations
,
February 2023 in “Biology” This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.
19 citations
,
December 2023 in “Journal of Investigative Dermatology” In this study, researchers found that the human hair follicle microbiota vary by anatomical compartment and donor age, with specific microbes like S. epidermidis potentially influencing hair follicle functions, which suggests new avenues for therapeutic targeting.
18 citations
,
July 2024 in “Frontiers in Immunology” This review explores the complex relationships between ferroptosis, anastasis, and chemoresistance in cancer therapy, highlighting the potential of combining ferroptosis with immunotherapy to overcome resistance and improve personalized cancer treatments.
17 citations
,
July 2024 in “Frontiers in Oncology” This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.