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Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Mechanical force is important for the first contact between skin cells and hair growth in mini-organs.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Modern hair restoration techniques have evolved from punch grafting to methods like micro-grafting and follicular unit transplantation, but they are labor-intensive, expensive, and can lead to patient dissatisfaction. Future treatments may involve cloned hair follicles and drugs like finasteride.

Hair transplant for eyebrow alopecia areata provided significant relief and improved treatment response.

Hair transplantation has improved with techniques that increase graft survival and patient satisfaction for more natural results.

Hair restoration surgery can effectively increase pubic hair density, with patient satisfaction and natural results largely depending on the chosen hair pattern and graft design.

Patients with alopecia areata should be checked for muscle spasms, diarrhea, and ANA to avoid missing Satoyoshi syndrome.

Hair transplants can temporarily help with eyebrow hair loss.

Hair transplantation can effectively treat female pattern hair loss with the right patient selection and surgical skill.

The article concludes that hair transplantation is advancing, but a reliable way to ensure complete tumor removal is still needed.

Hair transplant surgery in India has progressed from plugs and flaps to advanced techniques using micrografts and follicular unit extraction.

The document corrects a missing conflict of interest and acknowledges a pioneer in hair transplantation and his other contributions.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Pubic hair transplantation can help women with little to no pubic hair, using scalp hair for a natural look and requires careful aftercare.

The Frechet flap technique effectively hides scalp surgery scars with good results and minimal issues.

Dense-packing hair grafting is a simple, safe, and effective way to restore hair in people with cicatricial alopecia.

Hair transplant is effective for treating hair loss caused by radiation and improves patients' quality of life.

The book "Hair Replacement" is a detailed guide on all methods of hair replacement, recommended for those interested in the field.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Scalp Roller therapy helped improve hair growth in patients with hard-to-treat alopecia areata.

Norman Orentreich pioneered hair transplantation, improving techniques over time for more natural results.

Intralesional corticosteroids are the best for limited alopecia areata, oral steroids are less effective, and PRP is safe and promising, especially for children and severe cases.

Tofacitinib is effective for severe alopecia areata, similar to oral betamethasone.

Surfactants in spanlastics improve drug delivery by making nanovesicles more flexible and stable for painless administration through the mouth.

Combining OMP with cyclosporine can effectively treat severe alopecia areata in children.

Systemic corticosteroids can help treat rapidly spreading vitiligo but require more research for safer use.

Some people with severe, long-lasting baldness responded well to a specific combination treatment.

The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.