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Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The Rotterdam Study aims to understand various diseases in older adults.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.

Dermatologists need to understand hair products to treat hair and scalp issues better.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Oestrogens are key for bone growth during puberty in both boys and girls.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Chemotherapy-induced hair loss significantly affects patients' well-being, and nurses are key in helping them cope, but more research is needed to find effective treatments.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

One minoxidil-sensitive potassium channel exists in human hair follicles.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.