Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.

In this study, the authors found that targeting mTORC1 with rapamycin inhibited TPA-induced skin tumor promotion by affecting keratinocyte proliferation, including critical stem cell populations in the mouse epidermis.

This study found that Stat3 deletion in certain skin cells led to increased differentiation and altered stem cell behavior, suggesting its significant role in skin tumor development and keratinocyte migration.

This study found that KLF4 expression in mouse hair follicle stem cells is important for effective cutaneous wound healing, with its knockdown leading to reduced stem cell populations and delayed healing.

This study found that epidermal melanocytes can regenerate hair follicles, whereas non-cutaneous or dermal melanocytes cannot, suggesting two distinct melanocyte lineages with potential implications for melanocyte-related diseases.

This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.

This study found that the phenotype of Hedgehog/Gli-driven skin tumors in mice depends on the cell of origin, tissue context, and level of oncogenic signaling.

This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.

This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.

This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.

In this study, researchers used single-cell RNA sequencing to define and locate three distinct cell states of melanocytes in mouse skin development, potentially aiding the understanding of abnormal melanocyte differentiation.

This study found that mutant mice with the we/we wal/wal genotype exhibit significant defects in hair shaft structure and epidermis stratification, correlating with postnatal alopecia symptoms.

This study reports that plasma rich in growth factors appeared to improve hair follicle regeneration and patient satisfaction in individuals with androgenetic alopecia, though further trials are needed.

In this study, researchers observed that the sebaceous gland niche in mice allows for Wnt-induced hair follicle differentiation, unlike the non-permissive bulge.

This study found that MED1 deficiency in keratinocytes accelerates skin wound healing in young mice but delays healing in older mice, suggesting differential roles in epidermal regeneration with age.

This study identified specific markers that can distinguish between stem cells in different regions of human scalp hair follicles, offering potential strategies for cell sorting and purification based on these markers.

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.

This review discusses the migration and colonization of melanocytes from the neural crest in mammals and reports no new experimental results.

Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.

This review discusses melanocyte development, emphasizing the plasticity of melanoblasts and the role of both intrinsic and extracellular signals in their differentiation and migration, with no new clinical results reported.

This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.

This study found that in scarring alopecia, stem cells are differentially localized, suggesting that both inner and outer root sheath stem cells, rather than just follicular bulge stem cells, are involved.

This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.

This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.

Different types of stem cells and their environments are key to skin repair and maintenance.

This study found that constitutively active Stat3 in transgenic mice led to reduced keratinocyte stem cell populations in hair follicles, altering stem/progenitor cell dynamics and homeostasis.

This review discusses the various stem cell populations associated with hair follicles and their potential in regenerative medicine, highlighting differences between murine and human hair follicles but reports no new clinical results.

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.