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The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

Hair growth is cyclic and influenced mainly by local factors.

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Polycystic ovary syndrome is found in 6.5% of unselected Caucasian women in Spain.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Testosterone therapy increases bone density in older men with low testosterone levels.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

β-catenin is essential for stem cell activation and proliferation in hair follicles.