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In this study, researchers developed a relatively simple punch assay for regenerating hair follicles using mouse or human cells, finding efficient hair formation with mouse cells but low efficiency with human cells on reconstituted human skin.

This study suggests that newly developed micro-pigment-encapsulated biodegradable microneedles accurately implant pigments in pig cadaver skin, potentially advancing scalp micro-pigmentation methods.

This study observed that cutaneous microwounds created by fractional photothermolysis heal differently from typical wounds, displaying rapid re-epithelialization and limited inflammation, which may help reduce scar formation by delaying collagen remodeling and minimizing myofibroblast activation.

This study found that using a 0.5mm roller for microneedle therapy increased hair growth in mice and significantly affected the expression of hair growth-related molecules like VEGF.

This study suggests that applying a suspension of adipose-derived cells during hair transplantation may enhance wound healing and promote continued hair growth shortly after the procedure.

This case study observed that high-intensity focused ultrasound treatment significantly improved hair density and reduced hair loss in a female patient with androgenetic alopecia, with no adverse events reported.

This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.

This study found that autologous micro-grafts improved wound healing and reduced pain in leg ulcers unresponsive to routine treatments within one week, lasting up to a month.

This review explores the mechanisms, techniques, and clinical applications of microneedling, highlighting its advantages and challenges in skin rejuvenation, and discusses future innovations in the field as it continues to evolve.

This study found that transtherapy, a treatment using Korean medicine, significantly improved acne scars, reducing the scarring grade from an average of 3.5 to 1.5 in moderate and severe cases.

This review discusses the cosmetic applications and healing phases of microneedling and reports no new clinical findings; the authors highlight its use for skin and hair treatments without epidermal damage.

This study tested a microneedle patch on rabbit and pig models to support skin regeneration, revealing that the treatment accelerated wound closure, reduced scar formation, and promoted hair-bearing tissue and follicle growth, suggesting a trauma-guided framework for skin restoration.

This study developed multifunctional microneedle patches with CTB nanozymes that successfully eradicated MRSA infections in wounds by combining near-infrared laser-induced nitric oxide release and local hyperthermia, while also regulating oxidative stress, inflammation, and angiogenesis through specific signaling pathways.

This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

In this preliminary study, topical treatment with oxygen-carrying micro/nanobubbles hastened the healing of full-thickness burn wounds in a rodent model, compared to saline-treated controls.

This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.

This study found that using a Picosecond IR Laser (PIRL) on mouse skin led to less tissue damage and scarring compared to conventional surgical lasers and tools.

This study proposes a metal-organic gel-encapsulated microneedle system with antibacterial, anti-inflammatory, and pro-angiogenic properties for treating infected wounds, demonstrating potential for precise and adaptive management by targeting various stages of wound healing.

In this study, researchers developed injectable micropore-forming hydrogels that enhance tissue adhesion strength and promote wound healing by allowing better cell infiltration and inducing hair follicle regeneration in skin incision wound models.

In a swine model, this study found that a novel micro-coring needle device increased skin thickness and collagen content, suggesting potential as a safer, cost-effective alternative to laser resurfacing for skin rejuvenation.

This study found that a newly created biomimetic microneedle platform effectively expedited wound repair in diabetic animal models by reducing inflammation, enhancing angiogenesis, and promoting skin regeneration through targeted drug delivery and immune response modification.

In this study, AFM-based indentation was used to assess mechanical properties of murine skin wounds at two healing stages, revealing that early wounds exhibit stiffer hyperproliferative epithelium compared to granulation tissue, and highlighting significant influences of surface roughness on tissue stiffness measurements.

This study found that repeated microneedle stimulation in mice promoted hair growth and increased the expression of hair-growth-related genes, suggesting potential therapeutic uses for alopecia.

This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.

This study demonstrated that in a mouse melanoma wound model, the MQ Microneedles effectively managed ROS levels to inhibit tumor growth and promote wound healing through light-controlled release.

The microneedle arrays effectively promote wound healing and have potential for clinical use.

This review discusses micro needling as a therapeutic option for various dermatological conditions, such as scars and pigmentation, and reports no new clinical results; the authors note potential side effects and contraindications.

This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.