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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

COVID-19 can cause different skin symptoms that may help with early diagnosis and show how severe the disease is.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Latanoprost can make eyelashes longer, thicker, and darker.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Hair loss linked to higher heart disease risk in both men and women.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

The document concludes that diagnosing and treating Human African Trypanosomiasis is challenging, but new treatments like fexinidazole are promising.

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

Minoxidil promotes hair growth but stops working when discontinued.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.