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This mini-review reports that advances in microbioreactor technology, particularly with microfluidics, significantly enhance eukaryotic cell-based biomedicine by improving productivity, scalability, and reproducibility in applications like CAR T-cell manufacturing and organoid growth, though challenges in scalability and material selection remain.

This study reported that using micronized-gingival connective tissues appeared safe and showed initial efficacy for reconstructing peri-implant soft tissues, suggesting potential as an alternative to traditional grafting methods.

Microfluidic models improve testing for aging, wound healing, and oral tissue, reducing animal testing.

This study developed microfluidics-based 3D microtumors to model minimal residual disease in ovarian cancer, highlighting their alignment with patient-derived MRD and response to a fatty acid oxidation inhibitor.

This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.

This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.

This study used digital-light-processing bioprinting to create a 3D skin-on-a-chip model with a miniaturized vascular network to closely study immune cell interactions similar to real human skin, demonstrating the potential to analyze immune-T cell trafficking influenced by skin signals.

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

This review outlines the current state and future prospects of using layer-by-layer self-assembly for cell encapsulation in biomedical applications, such as cell-based biosensors, transplantation, and tissue engineering, while also discussing its limitations and potential advancements.

This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.

This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.

This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.

This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.

This study developed a method for generating germ-like tissues called bbHFGs, which efficiently promoted hair follicle formation in mice, potentially advancing hair regenerative medicine applications.

This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.

This study demonstrated a method for large-scale preparation of self-sorted hair follicle germs in vitro, which successfully generated hair follicles when transplanted into the skin of nude mice.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.

This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.

This study demonstrated that an engineered human skin equivalent can generate follicle-like structures resembling fetal skin, highlighting the role of the dermal compartment in directing epithelial cell fate in vitro.

This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.

This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.

The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.

This review discusses the current challenges and strategies in hair follicle bioengineering for treating hair loss and reports no new clinical results; it highlights ongoing hurdles and future directions for developing functional hair regeneration therapies.

This study found that ginsenoside Rb1 promoted the growth of mink hair follicles and dermal papilla cells, potentially through activating the PI3K/AKT/GSK-3β signaling pathway.