22 citations
,
January 2017 in “Advanced Healthcare Materials” This study found that thermoresponsive hydrogels can maintain mechanical memory in fibroblasts, enhancing wound healing compared to traditional trypsinized methods.
21 citations
,
January 2023 in “Biomaterials Science” This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.
21 citations
,
October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
20 citations
,
October 2021 in “PLoS ONE” This study found significant differences in gene expression between newborn and adult skin, with infant skin notably increasing processes related to ECM organization, cell adhesion, and collagen fibril organization.
19 citations
,
August 2019 in “Expert Opinion on Therapeutic Targets” This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.
17 citations
,
December 2019 in “Stem Cells International” This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.
17 citations
,
February 2019 in “PubMed” This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.
14 citations
,
February 2021 in “Experimental Dermatology” This study found that activating CB1 receptor signaling in human hair follicles increased stem cell proliferation while reducing differentiated cell survival, suggesting CB1's role as a survival stimulus for epithelial stem cells.
14 citations
,
November 2020 in “International Journal of Biological Macromolecules” This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.
14 citations
,
August 2017 in “Dermatologic surgery” This review discusses strategies for achieving natural results in male facial aging treatments using dermal and subcutaneous fillers, but reports no new clinical outcomes.
13 citations
,
February 2018 in “Bio-medical Materials and Engineering” This study demonstrated that minoxidil-encapsulated PLLGA nanoparticles significantly increased minoxidil delivery to hair follicles compared to a minoxidil aqueous solution in mice.
11 citations
,
January 2024 in “Indian Journal of Pharmaceutical Sciences” This review summarizes the enhanced absorption and bioavailability of phytosome delivery systems, which combine herbal extracts with phospholipids to improve therapeutic potential, and provides an updated overview of their development, commercial availability, and patented technologies.
9 citations
,
May 2019 in “Vestnik dermatologii i venerologii” This study demonstrated a method for delivering a photosensitizer, Ammi majus fructuum furocumarines, into hair follicles using calcium carbonate particles, followed by UVA irradiation, which led to significant pigment accumulation, indicating potential improvements for photochemical therapy.
8 citations
,
June 2022 in “Frontiers in bioengineering and biotechnology” This study found that a collagen patch made with fibroblast-derived extracellular matrix (fdECM) extracted from human lung fibroblasts enhanced wound healing by promoting wound contraction, angiogenesis, and skin remodeling in full-thickness skin wound models, including those with diabetic ulcers.
8 citations
,
May 2021 in “Bioengineering & translational medicine” This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.
6 citations
,
November 2017 in “Dermatologic Therapy” In this study, researchers found that applying mometasone furoate 0.1% cream combined with adapalene 0.1% gel resulted in significantly greater hair regrowth over 12 weeks compared to mometasone furoate cream alone in patients with alopecia areata.
5 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This study introduced a simple and reliable in vitro assay capable of large-scale simultaneous screening of hair growth-promoting compounds using a 3D co-culture system of human dermal papilla and outer root sheath cells.
5 citations
,
January 2014 in “Current Dermatology Reports” This review discusses various treatments for adult acne in women, including topical, systemic, and alternative therapies, and reports no new clinical results.
4 citations
,
September 2024 in “Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics” This review discusses the potential of 3D cell cultures, particularly Patient-Derived Organoids, in advancing research on liposarcoma by addressing limitations of 2D cultures and animal models but reports no new experimental findings.
4 citations
,
January 2021 in “Archives of dermatological research” This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.
4 citations
,
December 2017 in “International Journal of Biomedicine” In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.
4 citations
,
March 2002 in “Journal of the American Pharmaceutical Association” This review discusses various skin conditions affecting women throughout their lives and highlights the pharmacist's role in advising on management and treatment, but it reports no new clinical results.
3 citations
,
May 2024 in “Amino Acids” This review identifies cysteine's central role in hair growth and its potential impact on Alopecia Areata's pathogenesis, suggesting examination of cysteine metabolism might clarify the disease's underlying mechanisms and lead to new treatments.
3 citations
,
January 2019 in “Advances in stem cells and their niches” This review discusses the role of dermal papilla cells in hair follicle morphogenesis and regeneration and reports no new results; the authors emphasize the importance of these cells in hair growth and pigmentation regulation.
2 citations
,
August 2020 in “Chemical and Pharmaceutical Bulletin” This study found that rubbing increased caffeine permeation into skin primarily via hair follicles, especially when applied against the natural hair direction.
2 citations
,
August 2020 in “Clinical, Cosmetic and Investigational Dermatology” This study found that a combination of oral compounds improved metabolic activity, cell viability, and proliferation in hair follicular keratinocytes, with L-cystine playing a key role in protection against oxidative stress.
2 citations
,
May 2017 in “InTech eBooks” This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.
2 citations
,
January 2011 in “Elsevier eBooks” This book reviews the various types of acne and acneiform conditions, as well as their treatment options, with expert insights from multiple fields.
2 citations
,
January 2009 in “Journal of Drug Delivery Science and Technology” This study found that cationic vesicles enhanced minoxidil skin retention and in vivo hair growth efficacy compared to other formulation types due to electrostatic interactions with the skin.
1 citations
,
October 2025 in “Frontiers in Bioengineering and Biotechnology” This study developed a multifunctional bilayer dressing containing nanosilver and basic fibroblast growth factor, which improved wound healing by preventing bacterial penetration, promoting angiogenesis and hemostasis, and accelerating cell proliferation and migration, outperforming a control group by increasing healing rates by 47% in vivo.