November 2025 in “Clinical Cosmetic and Investigational Dermatology” In this study, researchers suggest that digital microscopy using visible light could offer a more objective approach to diagnosing hirsutism by quantifying terminal hair, with future research needed to assess its usefulness in women with the condition.
This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.
May 2023 in “Experimental Dermatology” This study found that both reflectance confocal microscopy and optical coherence tomography can visualize detailed hair follicle abnormalities in various skin disorders, but larger, higher-quality studies are needed for clinical implementation.
October 2021 in “Journal of Investigative Dermatology” This study found no significant difference in SARS-CoV2 IgG seroconversion rates between patients with immune-mediated inflammatory diseases treated with targeted immune-modulating therapies and those on conventional systemic treatments.
January 2019 in “Global Dermatology” This review discusses the genetic disorder, monilethrix, characterized by fragile, brittle hair and its inheritance patterns, and reports no new clinical results.
September 2016 in “International Journal of Herbal Medicine” This study undertook powder microscopy and preliminary phytochemical analysis of Buxus wallichiana's stem bark and leaves, identifying steroids, alkaloids, saponins, and glycosides without reporting clinical outcomes.
October 2015 in “The American Journal of Gastroenterology” This case report observed a unique presentation of microscopic colitis with granulomatous inflammation in a patient whose symptoms resolved with budesonide treatment, suggesting a possible drug reaction, potentially linked to allopurinol.
January 2006 in “Dianzi xianwei xuebao” This study observed that ultrastructural changes like lamellar bodies and electron-dense granules in the stratum corneum may aid in the early diagnosis of Netherton syndrome.
January 1957 in “Nihon Chikusan Gakkaiho” This article examines microscopic structural differences and pigment distribution in various rabbit hair colors and reports no clinical results.
90 citations
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November 2014 in “Journal of Biomedical Optics” In this study, silver nanoparticles were found to penetrate porcine skin to depths ranging from 11.1 μm to 15.6 μm, potentially surpassing the stratum corneum thickness.
56 citations
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November 1958 in “The Journal of Cell Biology” This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.
50 citations
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December 2000 in “Journal of Pharmaceutical Sciences” This study found that electroosmotic flow through hair follicles significantly contributes to solution flow during iontophoresis in hairless mouse skin.
30 citations
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April 2009 in “Mycoses” This study found that the fungus Microsporum gypseum enzymatically degrades keratin in human hair, with the sequence of degradation reflecting the keratinization and cystine content of individual hair components in vitro.
28 citations
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September 1986 in “Pediatric dermatology” In this study, hair anomalies associated with acrodermatitis enteropathica in a young girl improved significantly after two years of zinc therapy.
24 citations
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September 2018 in “Lasers in Surgery and Medicine” This study shows that multiphoton microscopy can non-invasively distinguish between scarring and non-scarring alopecia by identifying certain morphological features, but further research is needed to confirm its clinical utility.
24 citations
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December 1957 in “Experimental Cell Research” This study observed that the glassy layer of hair follicles in guinea pigs consists of thick collagen-type fibrils organized into two distinct arrays, whereas in young mice, the fibrils are thinner and develop between the outer root sheath and fibroblasts.
18 citations
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May 2013 in “Journal of The American Academy of Dermatology” This study concludes that elastic tissue staining is the most reliable method for identifying scarring patterns in alopecia biopsy specimens, and polarized microscopy may provide specific insights for nonscarring alopecia.
7 citations
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August 2018 in “Journal of Cosmetic and Laser Therapy” This study proposes an innovative treatment for stretch marks by combining skinbooster and microneedling techniques, which induce tissue remodeling and collagen synthesis, and suggests using confocal microscopy as a valuable tool for monitoring skin changes in aesthetic dermatology.
7 citations
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January 2001 in “Comprehensive series in photosciences” This study found that UV stabilizers must diffuse uniformly and in high uptake levels throughout hair fibers during humidification cycles to effectively prevent photo-oxidative degradation.
5 citations
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March 2009 in “Pediatric Dermatology” The study found that pili bifurcati causes hair to intermittently split into two branches, each with its own outer layer.
3 citations
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September 2020 in “Molecular Brain” This study reports that Elvitegravir, a drug currently approved for other uses, shows potential as a neuro- and mitoprotective agent by attenuating mitochondrial damage caused by NMDA receptors in primary mouse cortical neurons.
2 citations
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January 2023 in “Skin Appendage Disorders” In this study, chemotherapy-induced alopecia in cancer patients showed specific trichoscopic patterns and abnormal hair shaft morphology, suggesting intermittent follicle damage from chemotherapy, but larger studies are needed for confirmation.
1 citations
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May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a custom-designed 3D-printed microscope stage insert for inverted confocal microscopes, enhancing the accessibility of long-term intravital imaging of live cell dynamics in live transgenic mice, particularly in the skin.
1 citations
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November 2004 in “International Journal of Cosmetic Science” In this study, synchrotron-powered infrared microscopy revealed that hair follicles are a favored penetration pathway for cyanophenol and ethylhexyl methoxycinnamate in human skin, without altering protein secondary structure.
1 citations
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August 1999 in “ACS symposium series” In this study, fluorescence microscopy revealed that a cationic cellulose ether derivative adsorbed onto hair fibers desorbed significantly when treated with sodium dodecylsulfate.
June 2026 in “Journal of Cutaneous Pathology” This study found that polarized light microscopy is more effective than diffractive microscopy in distinguishing scarring from non-scarring alopecia, providing a highly specific adjunct diagnostic tool for alopecia biopsy specimens.
May 2026 in “Jurnal Pendidikan Kimia Fisika dan Biologi” This study found that rebonding hair straightening treatments visibly damage the hair cuticle, causing surface erosion and cracks, as shown through Scanning Electron Microscopy analysis.
This pilot study employed in-vivo multiphoton microscopy to visualize pigment-producing melanocytes in vitiligo patients, aiming to enhance understanding of treatment impacts and potentially improve transplantation therapies.
This study shows that multiphoton microscopy can non-invasively distinguish scarring from non-scarring alopecia by identifying specific morphological features in hair follicle structures.
This review discusses the advancements and applications of multiphoton microscopy in dermatology, including its role in imaging skin disease and drug transport, and reports no new clinical results.