August 2018 in “Journal of Investigative Dermatology” This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.
January 2017 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi” This study found that hair damage from sunlight and chemical processes like perms and bleaching varies in internal microstructure changes, suggesting that protective techniques should be tailored to the type of chemical treatment used.
September 2016 in “Journal of Dermatological Science” Polarizing light microscopy can easily and reliably diagnose congenital keratinizing disorders like Netherton syndrome.
Hair movement can indicate hair quality and health.
January 2015 in “Chinese Veterinary Science” This study observed distinct changes in the ultrastructure of Hexi cashmere goat hair follicles throughout the year, highlighting stages with specific cellular and structural characteristics.
January 1994 in “Nihon Chikusan Gakkaiho” This study observed that mink dermal collagen fibrils undergo structural changes during the hair cycle, with increased fiber thickness and bundle density as minks grow.
August 1985 in “Proceedings ... annual meeting, Electron Microscopy Society of America/Proceedings, annual meeting, Electron Microscopy Society of America” This study investigated the effects of intensive hair dye use in mixed-breed dogs and found changes in the cuticle of the hair shaft and the epidermis using scanning electron microscopy.
99 citations
,
July 2005 in “Ultramicroscopy” This study analyzed the nanotribological properties of various hair types and human skin, revealing differences in friction and adhesion based on ethnicity and hair condition.
78 citations
,
July 1984 in “Journal of Investigative Dermatology” 57 citations
,
December 2012 in “Journal of Biomedical Optics” This review discusses the application of confocal laser scanning microscopy for studying nanoparticle interactions with skin and highlights its potential for broad applications, but reports no new experimental findings.
48 citations
,
January 2002 in “Journal of Structural Biology” This study reports that trichocyte intermediate filaments from rat vibrissae and human hair follicles may contain a hollow region at their core, suggesting unique structural properties.
46 citations
,
May 2006 in “Laser Physics” In this study, particles similar in size to keratin cells were surprisingly found to penetrate more efficiently into hair follicles due to a possible pumping effect from moving hairs.
39 citations
,
January 2011 in “Archives of Dermatology” This study found that the yellow dot pattern observed in dermoscopy of alopecia areata corresponds to inefficient follicular structures containing hair remnants, as corroborated by reflectance confocal microscopy and pathological findings.
33 citations
,
September 1987 in “American Journal of Medical Genetics” This study documents dominant transmission and complete penetrance of uncombable hair syndrome in a family, despite the father lacking visible abnormalities.
30 citations
,
September 2018 in “International Journal of Cosmetic Science” In this study, researchers observed that cosmetic peroxide bleaching causes oxidative damage and protein loss in human hair, not only affecting the cuticle but also deeper cortical structures, correlating with bleaching severity.
29 citations
,
April 2011 in “Journal of Microscopy” This study describes a modified reduction-osmication method for staining human scalp hair that improves reagent penetration and visualization of hair cortex features using transmission electron microscopy.
28 citations
,
June 1991 in “Veterinary Dermatology” This study observed that black-haired areas in female Saluki puppies developed hypotrichosis, with dilated hair follicles containing melanin clumps, while white-haired areas remained normal.
27 citations
,
November 2012 in “Journal of Biomedical Optics” This study used confocal Raman microscopy to confirm optical similarity between human and porcine hair follicles, supporting its use in assessing trans-follicular drug delivery.
26 citations
,
December 2009 in “Laser Physics” This study observed that caffeine-containing shampoo can penetrate hair follicles to a depth of approximately 200 μm and remains detectable even after 24 hours, suggesting a potential long-term reservoir effect.
24 citations
,
February 2007 in “Laser Physics Letters” This study found that a caffeine-containing shampoo penetrated deeply into hair follicles in just two minutes and remained there for up to 48 hours, even after washing.
21 citations
,
December 2016 in “European journal of pharmaceutics and biopharmaceutics” This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.
20 citations
,
October 2016 in “Veterinary dermatology” This study reports that generalized discoid lupus erythematosus is a recognized canine variant of cutaneous lupus erythematosus, resembling its human counterpart, with varied treatment responses and common relapses.
19 citations
,
April 2019 in “Journal of the European Academy of Dermatology and Venereology” This study found that acne lesion formation involves early hyperkeratinization and inflammation around hair follicles, creating a self-sustaining cycle that may progressively worsen acne.
18 citations
,
November 2007 in “Acta Veterinaria Hungarica” This article describes the structure of ovine interdigital sinuses using scanning electron microscopy, highlighting features such as dense secretory material, hair presence, and classical apocrine secretion characteristics.
17 citations
,
May 2016 in “Archives of Dermatological Research” This study identified specific reflectance confocal microscopy features that help differentiate scarring from non-scarring alopecia, providing a non-invasive diagnostic tool.
13 citations
,
January 2001 in “Pediatric dermatology” This study reports pseudopili annulati in a dark-haired Chinese girl, identifying the unique appearance and structural characteristics of her hair without finding abnormalities in the cuticle and cortex.
12 citations
,
May 2012 in “Journal of Biomedical Optics” In this study, Trichoscan®, reflectance confocal microscopy, and optical coherence tomography were found to be reliable noninvasive tools for measuring hair growth and follicle analysis after hair removal.
11 citations
,
January 2000 in “Journal of cosmetic science” This study found that hydrolyzed wheat proteins extensively penetrated both untreated and chemically treated hair, primarily occupying areas like the endocuticle and cortex.
10 citations
,
January 2020 in “Royal Society Open Science” This study developed a quantitative measure for scoring hair surface damage from SEM images and found it accurately classified hair damage caused by explosive blasts, similar to an existing classification system.
10 citations
,
January 2013 in “Journal of The European Academy of Dermatology and Venereology” In this study, a square pulse, low-fluence IPL device used at home significantly reduced terminal hair count by 87% six months post-treatment, with evidence of hair miniaturization similar to professional laser treatments.