This review discusses the advancements and applications of multiphoton microscopy in dermatology, including its role in imaging skin disease and drug transport, and reports no new clinical results.
January 2006 in “Dianzi xianwei xuebao” This study observed that ultrastructural changes like lamellar bodies and electron-dense granules in the stratum corneum may aid in the early diagnosis of Netherton syndrome.
January 1994 in “Medical Entomology and Zoology” This article reviews various microscopy techniques and their applications in dermatology but reports no new experimental results.
January 1957 in “Nihon Chikusan Gakkaiho” This article examines microscopic structural differences and pigment distribution in various rabbit hair colors and reports no clinical results.
20 citations
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January 2015 in “Polish Journal of Pathology” Reflectance confocal microscopy is a useful, non-invasive tool for diagnosing some skin diseases, with potential for future improvements.
5 citations
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August 2021 in “STAR Protocols” This article outlines a protocol for scanning electron microscopy of murine skin and primary keratinocyte monolayers, providing a guide for sample preparation and examination.
4 citations
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April 2020 in “Dermatology practical & conceptual” This review outlines the practical use of reflectance confocal microscopy in dermatology, detailing its applications and considerations for diagnosing various skin conditions, but reports no new findings.
1 citations
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January 2018 in “Journal of microscopy and ultrastructure” In this study, researchers used SEM/SDD-EDS to identify waterborne minerals like calcium and aluminum in the scalp hair cuticle of individuals using treated or untreated water for hair washing, finding that prior application of coconut oil or conditioners can prevent calcium uptake.
1 citations
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June 2012 in “Revista de la Escuela de Medicina Legal” This study found that using a microscope can effectively distinguish between human and animal hair based on microscopic characteristics, making it a critical tool in forensic investigations.
January 2026 in “Inflammation and Regeneration” This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.
January 2022 in “OPAL (Open@LaTrobe) (La Trobe University)” This study used advanced optical imaging techniques to investigate nanoparticle and dye penetration in human skin, finding that nanoparticles mainly resided in the stratum corneum and accumulated in skin folds and hair follicles, while highlighting that sunscreen-based nanoparticles appear unlikely to pose safety concerns.
56 citations
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March 2017 in “Plant and Cell Physiology” This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.
42 citations
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April 2008 in “Acta materialia” This study investigated the tensile response and morphological changes of different ethnic hair types using AFM, showing variations between virgin, chemically damaged, and conditioner-treated Caucasian hair under different conditions.
36 citations
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November 2011 in “Journal of the European Academy of Dermatology and Venereology” This study identified distinct microscopic characteristics of acne scars, including inflammatory infiltrates and insufficient collagen deposition, suggesting that treatment should consider these histopathological findings and employ combination therapy.
31 citations
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September 2016 in “PLoS ONE” The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.
26 citations
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April 2011 in “Skin Research and Technology” This study found that in vivo confocal scanning laser microscopy accurately quantifies neogenic hair follicles in mice, producing results similar to histology while avoiding fixation artifacts.
25 citations
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May 2019 in “Heliyon” This study found that excessive heat caused the most significant structural changes in hair from Caucasian and Afro samples, especially when combined with other treatments like bleaching and straightening.
25 citations
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December 2008 in “Journal of Dermatological Case Reports” In this study, R-CSLM showed promise in evaluating hair shaft diseases by providing high-quality images of hair structures, although further development is necessary for follicle and perifollicular area analysis.
25 citations
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October 1962 in “Journal of Ultrastructure Research” The hair follicle structure is more complex than thought, with new findings on protein formation.
24 citations
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January 1969 in “Archives of Dermatological Research” Hair malformations may occur due to timing issues in hair development.
20 citations
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April 2011 in “British Journal of Dermatology” Reflectance confocal microscopy can tell apart white dots on the scalp as either sweat gland ducts or hair follicle openings.
20 citations
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July 2010 in “Skin Research and Technology” This study found that aging in Korean individuals is associated with changes in hair diameter and surface structure, as observed through atomic force microscopy.
19 citations
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February 2013 in “Journal of Investigative Dermatology” Touch domes in human skin are complex sensory structures not directly linked to hair.
17 citations
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January 2011 in “Skin Research and Technology” Hair from people with seborrheic dermatitis is thicker scaled, more damaged, and thinner than healthy hair, and atomic force microscopy can help monitor the condition.
17 citations
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February 1987 in “Journal of the American Academy of Dermatology” This study observed that daily selenium sulfide shampoos successfully removed fungal spores hidden beneath the hair cuticle in patients infected with ectothrix Microsporum canis.
16 citations
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September 2016 in “Experimental Dermatology” This review provides guidance on using two-photon microscopy for real-time and long-term visualization of stem cell activity in live mice skin, focusing on its application in researching skin and stem cell biology.
14 citations
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July 2007 in “International Journal of Cosmetic Science” This study found that a new 3D image analysis method from SEM images enables quick and accurate measurement of cuticle scale heights in hair fibers.
13 citations
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September 2011 in “Archives of dermatology” This case report describes a 3-year-old male with X-linked ichthyosis and associated neurologic abnormalities, identifying an unusual cortical development malformation and suggesting that abnormal hair banding may assist diagnosis.
13 citations
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March 2006 in “International Journal of Cosmetic Science” The study found that a polymer treatment changes the charge on hair surfaces, making bleached hair smoother and less porous.