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This pilot study suggests that using growth factors followed by microneedle therapy may benefit women with female pattern hair loss.

This study found that HRHDT combined with microneedle therapy improved hair growth in a mouse model of alopecia more effectively than microneedle therapy alone.

In this study, Ganoderma lucidum extract combined with microneedle therapy promoted hair growth more effectively than microneedle therapy alone in a mouse model of alopecia.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

This review discusses the potential of microneedles in cancer diagnosis and treatment, highlighting advances and ongoing clinical trials, but reports no new results; it emphasizes the minimally invasive nature of this technology.

This study developed a microneedle system using black phosphorus nanosheets and baicalin for treating androgenetic alopecia, finding it effectively enhanced drug penetration and follicular targeting while showing synergistic efficacy and safety in preclinical tests, including in vivo model efficacy against testosterone-induced hair loss.

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

This study found that photodynamic therapy with methyl 5-aminolevulinic acid was ineffective for treating alopecia totalis, even with microneedle rolling to enhance drug delivery.

This article reviews microneedle technology as a transdermal drug delivery platform without presenting new clinical results, emphasizing its engineered microstructure arrays for enhanced penetration.

A new microneedle system may improve hair loss treatment by delivering ketoconazole directly to hair follicles.

This study developed and tested a novel microneedle treatment loaded with nanoparticles for vitiligo, leading to enhanced skin repigmentation by targeting immune cells and reducing oxidative stress in a minimally invasive manner.

This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.

This study found that combining scalp repair serum microneedles with oral and topical medications significantly improved hair regrowth in patients with moderate to severe androgenetic alopecia.

This study found that micro needle roller therapy enhanced hair follicle development and increased growth factor expression in C57BL/6 mice, suggesting potential benefits for alopecia treatment.

Microneedle roller therapy can help hair grow.

This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.

In this study, researchers developed a drug-free microneedle patch using chitosan lactate and stem cell-derived exosomes that significantly promotes hair regeneration in animal tests compared to minoxidil, highlighting its potential as a simple and efficient hair loss treatment.

This study found that among Chinese males with male androgenic alopecia, combination therapy using topical minoxidil and nano-microneedle-assisted fibroblast growth factor significantly improved hair density, diameter, and follicular unit density over 16 weeks, outperforming individual treatments.

In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.

This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.

This study demonstrates that a newly developed nanocomposite microneedle patch, releasing copper and zinc ions along with quercetin, effectively promotes hair follicle regeneration in androgenic alopecia by targeting various pathophysiological aspects of hair loss.

This study observed that a course of micro needle mesotherapy improved hair and scalp condition in males with alopecia.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.

This review reports that microneedle-mediated transdermal drug delivery systems show promise in enhancing alopecia treatments by improving the efficacy of various therapeutic agents, including drugs, biologics, and stem cells, but highlights a gap between basic research advancements and clinical trial focus.

This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.

This study found that a machine-learning-driven strategy helped develop microneedles with high hardness and rapid dissolution, effectively promoting hair regrowth in androgenetic alopecia mice by activating the Wnt/β-catenin pathway, surpassing minoxidil's effects without biosafety risks.

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This review provides an overview of microneedle-assisted photomedicine, detailing diagnostic and therapeutic strategies, design principles, and challenges for translating this approach to skin disease management.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.