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In this study, microneedle-assisted human basic fibroblast growth factor therapy was reported to significantly improve hair regeneration in both male and female patients with androgenetic alopecia, alopecia areata, and telogen effluvium, showing greater effectiveness in males.

This review highlights the potential of microneedle devices in dermatology for conditions like skin aging and autoimmune skin diseases, emphasizing their ability to facilitate targeted drug delivery by creating temporary skin pathways.

This review discusses the potential of microneedles as a pain-free drug delivery method that improves medication distribution while addressing issues associated with traditional transdermal formulations.

In this study, a patch with microneedles regrew hair in shaved mice within six days, suggesting potential for treating hair loss in humans.

This study found that administering botulinum toxin A via Flex-PADs to mouse footpads inhibited sweating similarly to traditional injections, suggesting a promising patient-friendly delivery method for hyperhidrosis treatment.

This study developed and tested a novel microneedle treatment loaded with nanoparticles for vitiligo, leading to enhanced skin repigmentation by targeting immune cells and reducing oxidative stress in a minimally invasive manner.

This study explored chitosan-based dissolving microneedle arrays loaded with Agave tequilana root extract, finding that extract concentration influenced microneedle geometry and bioactivity, maintaining antioxidant and enzyme inhibitory effects while reducing collagenase inhibition, particularly in the 0.25% formulation.

In this study, researchers developed a probiotic-based microneedle system combining Weissella cibaria and clascoterone to target androgenetic alopecia, which in a mouse model improved hair density, vascular regeneration, and reduced inflammation, suggesting a promising treatment approach.

This study described a novel three-dimensional-printed microneedle system designed for improved transdermal delivery of minoxidil to treat hair loss, demonstrating effective hair regrowth and safety in a mouse model while allowing sustainable needle base recovery.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.

This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.

This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.

Hydrogel microneedles with special nanoparticles and growth factor improve hair growth better than minoxidil for hair loss treatment.

This study developed microneedles combining insulin-like growth factor-1 and type XVII collagen, showing more effective hair regeneration and reduced inflammation compared to minoxidil in a mouse model of androgenetic alopecia.

This study developed a dissolvable microneedle system loaded with nanozymes and minoxidil that enhanced hair regeneration in androgenetic alopecia mouse models by improving blood flow, reducing reactive oxygen species, and increasing cell proliferation compared to minoxidil alone.

This study found that microneedles containing magnetic intracellular vesicles and tremella polysaccharide improved the hair microenvironment and accelerated hair regeneration in mice with androgenic alopecia.

A new microneedle system with minoxidil nanoparticles effectively promotes hair regrowth with fewer side effects.

This study found that combining scalp repair serum microneedles with oral and topical medications significantly improved hair regrowth in patients with moderate to severe androgenetic alopecia.

This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.

This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.

This study demonstrates that a newly developed nanocomposite microneedle patch, releasing copper and zinc ions along with quercetin, effectively promotes hair follicle regeneration in androgenic alopecia by targeting various pathophysiological aspects of hair loss.

This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.

This study found that coated microneedles promoted drug release effectively, comparable to marketed minoxidil solutions, with stable performance over 30 days at high temperatures.

This study suggests that sericin microneedles with antibacterial and directional traction functionalities may enhance infected wound healing by improving skin repair and inhibiting bacterial growth, indicating potential for clinical application.

This study discusses the expanding use of microneedles beyond transdermal drug delivery, highlighting recent advancements for treating hair loss, eye diseases, and oral disorders, while emphasizing future challenges in generalizing this technology.

This study found that microneedles based on polyphosphazene with green tea polyphenols significantly enhanced wound healing in a diabetic rat model.

This study concluded that controlled micro-injury induces hair regeneration and vitiligo repigmentation in mice, potentially through the Wnt/β-catenin pathway.

This study reported that polysaccharides from Astragalus roots could promote hair regeneration and optimize drug delivery when combined in innovative microneedles, effectively improving hair growth in mice with androgenetic alopecia.

PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

This study found that a machine-learning-driven strategy helped develop microneedles with high hardness and rapid dissolution, effectively promoting hair regrowth in androgenetic alopecia mice by activating the Wnt/β-catenin pathway, surpassing minoxidil's effects without biosafety risks.