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This study found that photodynamic therapy with methyl 5-aminolevulinic acid was ineffective for treating alopecia totalis, even with microneedle rolling to enhance drug delivery.

This study found that micro needle roller therapy enhanced hair follicle development and increased growth factor expression in C57BL/6 mice, suggesting potential benefits for alopecia treatment.

Microneedle roller therapy can help hair grow.

This review discusses the use of derma rollers for cosmetic purposes and their potential in transdermal drug delivery by summarizing evidence on their design, efficacy, safety, and concerns from preclinical and clinical reports.

This review explores the development and cosmeceutical applications of microneedles for skin treatment, without reporting new clinical results, emphasizing safety and public perception as key factors for commercialization.

This study found that topical valproate has minimal potential to cause skin irritation, suggesting it can be applied safely to human skin.

This review discusses micro needling as a therapeutic option for various dermatological conditions, such as scars and pigmentation, and reports no new clinical results; the authors note potential side effects and contraindications.

In this study, researchers developed a composite paste system using minoxidil-loaded nanoparticles and valproic acid, enhanced by roller-microneedles, which significantly stimulated hair regeneration and perifollicular vascularization in an androgenetic alopecia mouse model, reducing side effects compared to traditional treatments.

This study found that using a 0.5mm roller for microneedle therapy increased hair growth in mice and significantly affected the expression of hair growth-related molecules like VEGF.

This study developed a spring-driven microneedle booster that improved early and cumulative delivery of minoxidil, accelerating hair regrowth compared to traditional roller methods in an androgenetic alopecia model.

This study suggests that microneedling may be an effective and less painful treatment for vitiligo, offering benefits over traditional needle injections, particularly in challenging-to-treat areas like the extremities or stubborn regions.

This study found that repeated microneedle stimulation in mice promoted hair growth and increased the expression of hair-growth-related genes, suggesting potential therapeutic uses for alopecia.

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

This literature review conducted a comprehensive analysis of existing studies on micro-needling mesotherapy in dermatology and aims to offer a practical guide for its clinical application, though it provides no new experimental findings.

In this study, a home-use microneedle device combined with 5% minoxidil showed potential for enhancing hair growth in pattern hair loss over six months, although the observed improvements in hair count and patient assessments were not statistically significant compared to other treatments.

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This review provides an overview of microneedle-assisted photomedicine, detailing diagnostic and therapeutic strategies, design principles, and challenges for translating this approach to skin disease management.

This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.

This study found that both intradermal injection and derma roller techniques for QR678Neo® hair regrowth therapy improved androgenetic alopecia symptoms, with intradermal injections showing non-significantly better video-microscopic outcomes but more pain and erythema associated with derma rollers.

This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.

This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.

In this study, PRP treatment improved hair loss in 40 female patients with female pattern alopecia, with most progressing to better grades of hair coverage after 6 months, while only minor pain was occasionally reported as an adverse effect.

This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

Scalp Roller therapy helped improve hair growth in patients with hard-to-treat alopecia areata.