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TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Microneedling is promising for treating various skin issues but needs more research to confirm its effectiveness and safety.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

Improving skin barrier and using antifungal treatments can help manage dandruff.

Skin fat helps with body temperature control and has other active roles in health.

Layer-by-Layer self-assembly is promising for biomedical uses like tissue engineering and cell therapy, but challenges remain in material safety and process optimization.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Antioxidants can benefit skin health but should be used carefully to avoid negative effects.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Skin problems in COVID-19 patients are rare and may be due to the body's complex immune response or blood clotting issues.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

An imbalanced gut and lack of biotin can cause hair loss in mice.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

AMF inoculation boosts tea plant growth and nutrient absorption.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Certain bacteria and fungi are linked to healthy scalps and dandruff, suggesting that the scalp's microbial balance affects its health.

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.