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      Colon Cancer Stem Cells: Promise of Targeted Therapy

      research Colon Cancer Stem Cells: Promise of Targeted Therapy

      411 citations , April 2010 in “Gastroenterology”
      This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.
      The Dynamics of the Skin’s Immune System

      research The Dynamics of the Skin’s Immune System

      306 citations , April 2019 in “International Journal of Molecular Sciences”
      This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.
      The Rotterdam Study: 2014 Objectives and Design Update

      research The Rotterdam Study: 2014 objectives and design update

      266 citations , November 2013 in “European Journal of Epidemiology”
      This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
      Interrelation of Immunity and Tissue Repair or Regeneration

      research Interrelation of immunity and tissue repair or regeneration

      252 citations , April 2009 in “Seminars in Cell & Developmental Biology”
      This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.
      The Rotterdam Study: 2012 Objectives and Design Update

      research The Rotterdam Study: 2012 objectives and design update

      247 citations , August 2011 in “European Journal of Epidemiology”
      This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.
      Recent Advances on the Mechanisms of Kidney Stone Formation

      research Recent advances on the mechanisms of kidney stone formation (Review)

      235 citations , June 2021 in “International Journal of Molecular Medicine”
      This review discusses five potential mechanisms for kidney stone formation, including urinary supersaturation, Randall's plaques, sex hormones, the microbiome, and immune responses, and reports no new results.
      Molecular Mechanisms of Androgenetic Alopecia

      research Molecular mechanisms of androgenetic alopecia

      229 citations , August 2002 in “Experimental Gerontology”
      This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.
      The Rotterdam Study: 2010 Objectives and Design Update

      research The Rotterdam Study: 2010 objectives and design update

      219 citations , September 2009 in “European journal of epidemiology”
      This article discusses the rationale, design, major findings, and updated objectives and methods of the ongoing Rotterdam Study on various diseases, without reporting new research results.
      COVID-19 and Sex Differences: Mechanisms and Biomarkers

      research COVID-19 and Sex Differences

      185 citations , August 2020 in “Mayo Clinic Proceedings”
      This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.
      Alopecia Areata: Treatment Options and Efficacy

      research Alopecia areata

      182 citations , December 2017 in “Journal of the American Academy of Dermatology”
      This article reviews current and emerging treatments for alopecia areata, including Janus kinase inhibitors, highlighting variability in clinical outcomes and the lack of sustained remission.
      Effects of Sex Steroid Deprivation and Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

      research Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

      176 citations , August 2000 in “˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”
      In this study, cross-sex hormone therapy affected hair growth patterns differently, with estrogen reducing hair growth in male-to-female transsexuals and testosterone increasing it in female-to-male transsexuals; however, male typical hair diameters were not fully reached in the latter group after 12 months.
      Wound Healing and the Use of Medicinal Plants

      research Wound Healing and the Use of Medicinal Plants

      170 citations , September 2019 in “Evidence-based Complementary and Alternative Medicine”
      This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.
      Alopecia Areata: A Multifactorial Autoimmune Condition

      research Alopecia areata: A multifactorial autoimmune condition

      148 citations , December 2018 in “Journal of autoimmunity”
      This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
      The Immune Functions of Keratinocytes in Skin Wound Healing

      research The Immune Functions of Keratinocytes in Skin Wound Healing

      147 citations , November 2020 in “International Journal of Molecular Sciences”
      This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
      TGF-β Family Signaling in Stem Cells

      research TGF-β family signaling in stem cells

      132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”
      This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
      Tregs: Where We Are and What Comes Next?

      research Tregs: Where We Are and What Comes Next?

      130 citations , November 2017 in “Frontiers in Immunology”
      This review explores recent findings on regulatory T cells, focusing on their unique functions in non-lymphoid tissues and new mechanisms of action, but presents no original clinical results.
      Hormesis And Medicine: Biphasic Dose-Response Relationship

      research Hormesis and medicine

      127 citations , June 2008 in “British Journal of Clinical Pharmacology”
      This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.
      Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

      124 citations , October 2019 in “Frontiers in Immunology”
      This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.