10 citations
,
July 2023 in “Pharmaceuticals” This study explored the wound healing potential of a natural marine soft coral-derived nanoparticle-based gel in a diabetic excision wound model, finding it effectively regulates proinflammatory cytokines and inhibits enzymes related to wound healing.
10 citations
,
November 2021 in “Biomedicines” This review describes and compares the efficacy of bioregenerative therapies, specifically mesenchymal stem cells and platelet-rich plasma, for treating osteoarthritis, suggesting they may offer a less invasive and more effective alternative to surgery and conventional therapies.
10 citations
,
September 2020 in “Metabolites” This study found that metabolite levels in hair samples differ significantly by hair color and segment, leading to recommendations for best practices in hair metabolomic studies.
10 citations
,
March 1999 in “Comparative Haematology International” This study found that chronic administration of testosterone in mice induced an elevated EPO secretion response, possibly mediated through DHT, without affecting baseline EPO levels.
9 citations
,
January 2014 in “Molecular Genetics and Metabolism Reports” This study discovered that a specific G to C mutation in the ornithine aminotransferase gene is linked to the retarded hair growth phenotype in mice and may serve as a model for human gyrate atrophy.
9 citations
,
March 2012 in “Experimental dermatology” This meeting report discusses the first symposium on natural gene therapy for skin, preceding the 41st annual meeting of the European Society for Dermatological Research, and reports no new experimental findings.
8 citations
,
December 2022 in “International journal of molecular sciences” This review discusses phenotypic differences in testosterone production between mice and humans with HSD17B3 deficiency and reports no new findings; the authors highlight potential pathways and enzymes involved in testosterone synthesis.
8 citations
,
January 2017 in “Journal of Biological Chemistry” This study found that astrotactin-2 undergoes unique intramembrane proteolysis during maturation, revealing specific transmembrane topologies and substrate sequence requirements for cleavage.
8 citations
,
September 2004 in “Contact dermatitis” Avoiding dyed wigs and clothing improved severe allergic reactions in a woman treated with diphencyprone.
7 citations
,
June 2021 in “Cell Proliferation” This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.
7 citations
,
July 2020 in “Pigment cell & melanoma research” In this study, RT1640 was found to promote hair pigment system regeneration and expand melanocyte stem cell pools in a mouse model, suggesting potential applications for aging-related hair disorders.
7 citations
,
May 2019 in “European Journal of Human Genetics” This study describes three new cases of MCOPS6 with BMP4 variants, noting expanded phenotypic variability but no clinically apparent microphthalmia in these individuals, which is commonly reported in the disorder.
7 citations
,
May 2005 in “Experimental Dermatology” This study reports that two mouse models of scarring alopecia exhibit similar patterns of hair loss progression despite histological differences in inflammatory cell localization and MHC class I expression.
6 citations
,
June 2022 in “Journal of Clinical Medicine” This study found that for men with moderate-to-severe LUTS/BPH, 6 months of treatment with tamsulosin plus the hexanic extract of S. repens was as effective as tamsulosin plus a 5-alpha-reductase inhibitor but had better tolerability.
6 citations
,
April 2022 in “Biomedicine & pharmacotherapy” This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.
6 citations
,
April 2010 in “Cellular Reprogramming” The study characterized the transcriptional changes in porcine SKP cells transitioning to fibroblast-like cells, indicating potential roles for specific signaling pathways in this cell fate transition.
6 citations
,
October 1979 in “Chest” This study found that minoxidil significantly reduces systemic blood pressure and vascular resistance in patients with hypertension, but does not alter pulmonary vascular resistance or exacerbate pulmonary hypertension.
5 citations
,
January 2025 in “Cancers” This article discusses the importance of optimizing treatment protocols for chemotherapy-induced alopecia and reports no new clinical results; the authors emphasize improving patient outcomes and quality of life.
5 citations
,
November 2024 in “Biomedicine & Pharmacotherapy” This study developed a carbohydrate chitosan-based biomaterial combined with a novel peptide to promote the chondrogenic differentiation of human adipose-derived stem cells, suggesting potential clinical applications for cartilage regeneration.
5 citations
,
February 2022 in “International Journal of Molecular Sciences” This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.
5 citations
,
December 2021 in “Journal of Investigative Dermatology” This study observed that Hedgehog signaling in reticular and papillary fibroblast lineages plays different roles in wound repair and de novo hair follicle formation.
5 citations
,
October 2019 in “JAAD Case Reports” This case report describes a young man with rapidly progressive cicatricial alopecia that shows features overlapping several other types, suggesting these conditions may exist on a spectrum.
5 citations
,
August 2019 in “iScience” In this study, Trf1 genetic deletion in mice, including those with cancer-prone mutations, was shown to not affect overall viability and cause only mild effects, while being necessary for tumor formation, suggesting a potential therapeutic window for Trf1 as an anti-cancer target.
4 citations
,
September 2024 in “Cell Reports” This study found that mice lacking the CXCR2 receptor regenerated tissue scarlessly in various injury models and that administering plasma or G-CSF from these mice to wild-type mice also reduced scarring, suggesting potential therapeutic strategies to improve human skin wound healing.
4 citations
,
April 2021 in “Experimental and Molecular Medicine” This review examines host factors like ACE2 and TMPRSS2 in SARS-CoV-2 infection, exploring how genetic variants and advanced cellular analyses might clarify COVID-19's severity and heterogeneity; it reports no new results.
4 citations
,
May 2019 in “Reproductive Endocrinology” This article reviews the causes and diagnosis of hyperandrogenism, highlighting its impact on female fertility and the metabolic risks associated with PCOS, but it provides no new clinical results.
4 citations
,
February 2016 in “Clinical Pharmacology & Therapeutics” Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.
4 citations
,
September 2011 in “Journal of the American Academy of Dermatology” This case report describes a 46-year-old man who developed folliculotropic mycosis fungoides, a form of post-transplant lymphoproliferative disorder, following renal transplantation.
3 citations
,
November 2024 in “Electrochimica Acta” A new, quick method accurately detects minoxidil in drugs and cosmetics.
3 citations
,
August 2022 in “Pharmaceuticals” This study observed that a self-emulsifying drug delivery system for finasteride significantly enhanced bioavailability in rats compared to commercial tablets, but the formulation was found to be thermodynamically unstable.