4 citations
,
November 2017 in “PubMed” This study found that Synsepalum dulcificum seed oil hair treatment significantly reduced hair breakage and improved hair health indices in women, outperforming both placebo and argan oil treatments.
This study reports that patients with specific MFN2 mutations, including p.Arg707Trp, exhibit significant upper body fat overgrowth with suppressed leptin production, suggesting tissue-selective mitochondrial dysfunction and potential therapeutic targets.
This study suggests that specific mutations in the MFN2 gene, including the p.Arg707Trp allele, can result in tissue-selective mitochondrial dysfunction leading to excessive upper body fat growth and low leptin levels.
December 2024 in “Food Bioscience” In a depilation mouse model, this study found that Limosilactobacillus fermentum MF10 promoted hair growth and increased follicle size by activating skin Wnt/β-catenin signaling and modulating gut microbiota, with effects comparable to the positive control finasteride.
101 citations
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March 2019 in “Cell Stem Cell” This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.
November 2023 in “Brain Sciences” This study investigated medications potentially linked to male-factor infertility using the FDA Adverse Event Reporting System and found that finasteride, testosterone, valproate, and other drugs showed significant disproportionate reporting of infertility cases, highlighting a potential under-reporting issue to regulatory bodies.
288 citations
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June 2009 in “Human reproduction update” This review examines various methods for assessing hair growth in women, highlighting the usefulness of the mFG visual scoring method for diagnosing hirsutism despite its limitations.
98 citations
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July 2011 in “Fertility and Sterility” This study determined that an mFG score of 5 or greater defines hirsutism among Southern Chinese women, with prevalence and score thresholds decreasing with age.
63 citations
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August 2022 in “Diagnostics” This review discusses hirsutism in women with PCOS who present with normal androgen levels and highlights diagnostic challenges, reporting no new clinical findings.
52 citations
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March 2016 in “JAMA dermatology” This study found that hirsutism significantly negatively impacts quality of life, with self-assessed severity more strongly linked to quality-of-life impact and depressive symptoms than clinician assessments.
39 citations
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October 2010 in “Journal of The American Academy of Dermatology” This study reported that alopecia occurred in 2.5% of patients with mycosis fungoides or Sézary syndrome, with some cases resembling alopecia areata and others associated with specific skin lesions.
37 citations
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August 2012 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” In this study, a modified Ferriman-Galwey score greater than 4 was found to be effective for diagnosing hirsutism in Asian women, highlighting key areas such as the upper lip, thighs, and lower abdomen.
28 citations
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April 2013 in “Fertility and Sterility” This study found that Caucasian and Asian women with PCOS in the San Francisco Bay Area had a similar prevalence of androgen excess, including hirsutism, across most measures.
25 citations
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December 2017 in “The Journal of Clinical Endocrinology & Metabolism” This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.
24 citations
,
April 2021 in “BMC women's health” This study found that women with PCOS and high BMI exhibited significantly increased hair growth compared to non-PCOS women, suggesting an additive effect of body weight on this phenotype in PCOS.
22 citations
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January 2019 in “Endocrinology and metabolism” This study found that among Filipino women, a modified Ferriman-Gallwey score of 7 or above indicates hirsutism and is significantly associated with elevated calculated free testosterone.
15 citations
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January 2014 in “Dermatology” This case report describes alopecia universalis-like hair loss occurring in two patients with cutaneous T cell lymphoma, providing clinical, dermoscopic, and pathologic features to help differentiate it from alopecia areata universalis.
13 citations
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June 2018 in “Journal of Womens Health” This study found that in women with PCOS, suppressive therapy using spironolactone plus oral contraceptives improved hirsutism more effectively than either treatment alone, with initial scores predicting success.
13 citations
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January 2012 in “International Journal of Trichology” In this study, idiopathic hirsutism was identified as the most common cause of hirsutism among the participants, with a significant difference in hormone levels between cases of polycystic ovarian syndrome and idiopathic hirsutism.
10 citations
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January 2018 in “Organogenesis” This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.
10 citations
,
June 2010 in “Fertility and Sterility” In this study, patients with polycystic ovary syndrome self-reported higher hirsutism scores compared to clinician assessments, but only clinician scores correlated with biochemical markers of hyperandrogenism.
8 citations
,
May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
7 citations
,
October 2020 in “Journal of Clinical Medicine” In this study, researchers found that overweight and obese women with polycystic ovary syndrome showed adverse changes in glucose metabolism over time, highlighting the importance of early intervention to prevent cardiometabolic diseases.
7 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found that the quality of life in Turkish women with hirsutism is significantly more affected when PCOS is present, but is not correlated with the hirsutism severity score.
6 citations
,
October 2014 in “Endokrynologia Polska” This study found that hirsutism is more prevalent in Chinese women with PCOS compared to the general population, and the Ferriman-Gallwey score is a good predictor for diagnosing PCOS in this group.
5 citations
,
July 2020 in “PubMed” This study found that EE/CPA and EE/DES were both effective in reducing hirsutism in patients with PCOS, with no additional benefit from adding low-dose metformin.
4 citations
,
January 2020 in “Genes” This study found that genetic variation in the KRTAP21-2 gene among crossbred Merino lambs was associated with differences in wool traits, particularly mean staple length.
3 citations
,
March 2016 in “Practical radiation oncology” This paper reviews total skin electron therapy for mycosis fungoides and reports no new results; the authors focus on dose de-escalation's impact on toxicity and response rates.
3 citations
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October 2021 in “Postepy Dermatologii I Alergologii” This study found that evaluating terminal hair growth on the chin, thighs, and either the upper lip or lower abdomen could streamline the modified Ferriman-Gallwey scoring, aiding hirsutism diagnosis under pandemic conditions.
2 citations
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January 2019 in “Annals of Dermatology” This preliminary study found that Melandrium firmum extract may promote hair growth and inhibit 5α-reductase, suggesting potential as a candidate for treating androgenetic alopecia.