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Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Human skin can make serotonin and melatonin.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Finasteride effectively treats BPH, but needs more trials to understand potential.

PGD2 stops hair growth and is higher in bald men with AGA.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

Fungi-produced compounds can change plant root growth.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Biotinidase deficiency has various symptoms and can be treated with biotin supplements.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Minoxidil effectively lowers blood pressure with few side effects.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.