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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

No single treatment is consistently effective for alopecia areata, and more research is needed.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Finasteride improves hair loss in women with hyperandrogenism.

Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

Treatments for melanin disorders exist, but more effective options needed.

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

About 13% of women had idiopathic hirsutism and 8.5% had polycystic ovary syndrome in a group of Iranian women.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.

The document concludes that correct diagnosis and management of PCOS are important, and more research is needed on its risks and treatments.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.

Scalp cooling is largely ineffective in preventing hair loss from breast cancer chemotherapy.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.