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    Glossary Metformin

    oral diabetes medication that lowers blood sugar levels

    Metformin, also known by brand names such as Glucophage, is an oral medication commonly used to manage type 2 diabetes. It works by reducing glucose production in the liver and improving the body's sensitivity to insulin, thereby helping to control blood sugar levels. Additionally, metformin is sometimes used off-label for conditions like polycystic ovary syndrome (PCOS) due to its effects on insulin resistance.

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    1. Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008 · 343 citations
    2. Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome European journal of endocrinology · 2009 · 200 citations
    3. Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome 2003 · 192 citations
    4. Short-term combined treatment with liraglutide and metformin leads to significant weight loss in obese women with polycystic ovary syndrome and previous poor response to metformin European journal of endocrinology · 2013 · 116 citations
    5. Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality Human reproduction · 2006 · 105 citations
    6. Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance European journal of endocrinology · 2007 · 91 citations
    7. The effect of metformin on hirsutism in polycystic ovary syndrome European journal of endocrinology · 2002 · 90 citations
    8. Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome (PCOS): A Six-Month, Open-Label Randomized Study The Journal of Clinical Endocrinology and Metabolism · 2013 · 75 citations
    9. Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: A randomized, double-blind, and placebo control trial Gynecological Endocrinology · 2010 · 60 citations
    10. Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome European journal of endocrinology · 2008 · 56 citations
    11. Metformin in dermatology: an overview 2013 · 51 citations
    12. Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome Diabetologia · 2017 · 50 citations
    13. Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome. European journal of endocrinology · 2008 · 40 citations
    14. The effect of weight loss and treatment with metformin on serum vaspin levels in women with polycystic ovary syndrome Endocrine Journal · 2011 · 38 citations
    15. Metformin influence on hormone levels at birth, in PCOS mothers and their newborns Human reproduction · 2009 · 35 citations
    16. The Efficacy of 24-Month Metformin for Improving Menses, Hormones, and Metabolic Profiles in Polycystic Ovary Syndrome The Journal of Clinical Endocrinology & Metabolism · 2018 · 33 citations
    17. Comparison clinical and metabolic effects of metformin and pioglitazone in polycystic ovary syndrome Indian journal of endocrinology and metabolism · 2016 · 26 citations
    18. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo Neuroscience Letters · 2014 · 26 citations
    19. Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin JAAD Case Reports · 2020 · 24 citations
    20. Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome Health and Quality of Life Outcomes · 2016 · 19 citations
    21. Impact of Treatment with Rosiglitazone or Metformin on Biomarkers for Insulin Resistance and Metabolic Syndrome in Patients with Polycystic Ovary Syndrome Journal of diabetes science and technology · 2007 · 19 citations
    22. Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment Clinical Endocrinology · 2015 · 18 citations
    23. The Utility of Metformin Therapy in Reproductive-Aged Women with Polycystic Ovary Syndrome (PCOS) Current Pharmaceutical Biotechnology · 2014 · 18 citations
    24. The Relationship Between Metformin and Serum Prostate‐Specific Antigen Levels The Prostate · 2016 · 17 citations
    25. Increased Insulin Sensitivity by Metformin Enhances Intense-Pulsed-Light-Assisted Hair Removal in Patients with Polycystic Ovary Syndrome Dermatology · 2008 · 17 citations
    26. Use of metformin in pediatric age Pediatric diabetes · 2011 · 16 citations
    27. Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms Fertility and sterility · 2010 · 15 citations
    28. Development of a new GC–MS/MS method for the determination of metformin in human hair Drug Testing and Analysis · 2020 · 14 citations
    29. The Effect of Alfacalcidiol and Metformin on Phenotype Manifestations in Women with Polycystic Ovary Syndrome – a Preliminary Study Physiological Research · 2016 · 14 citations
    30. The investigation and management of severe hyperandrogenism pre- and postmenopause: Non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin Gynecological Endocrinology · 2008 · 14 citations