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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Polymeric nanoparticles show promise for treating skin diseases.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Flutamide rarely causes liver toxicity in prostate cancer patients.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Mice with human skin protein K8 had more skin problems and cancer.