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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Biotin deficiency in patients on total parenteral nutrition can cause serious symptoms but can be treated with biotin supplements.

Understanding glycans and enzymes that alter them is key to controlling hair growth.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Taiwanese women with PCOS experience different symptoms based on age, with younger women facing more hormone imbalances and older women dealing with more metabolic issues.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

HSL treatment speeds up hair growth and reduces oxidative stress in hair follicles of ob/ob mice.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Storing hair follicles in special buffers with added protective substances can increase hair growth and reduce cell death.

Sebocytes play a key role in controlling androgen levels in human skin.

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and budesonide, which improved after stopping the medications.

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and inhaled budesonide.

Biotin supplements can effectively treat hair loss and skin issues in certain enzyme deficiencies.

Cobalt is important for health but too much or too little can cause health problems, and its environmental buildup is a concern.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Bariatric surgery improves skin conditions and metabolism but may cause nutritional deficiencies and hair loss.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Women with PCOS are more likely to have fatty liver disease and worse metabolic health.