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The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

The conclusion is that early diagnosis and a multi-system treatment approach are crucial for managing PCOS and its associated health risks.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Young Czech women with PCOS have a higher risk of heart problems and should be regularly checked for cholesterol and glucose issues.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

Mutations in the HEPHL1 gene cause abnormal hair and cognitive issues.

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.

High levels of male hormones are very common in women with PCOS and affect their metabolism differently depending on their weight.

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.

Higher hair calcium to magnesium ratios and lower chromium levels in hair may indicate insulin resistance in Korean men.

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

Green tea component EGCG helps keep rat skin grafts viable longer.

Zinc is essential for many body functions and imbalances can lead to health problems.

Personalized diets, like the Mediterranean Diet and low carb diets, can help manage PCOS symptoms in obese women, and probiotics may enhance weight loss and improve metabolic health. More research is needed to find the best diet strategies.

New treatments targeting fibrosis could improve urinary symptoms in BPH.

Manage PCOS in primary care with weight loss, psychological support, medication, and monitoring for health risks.

Finasteride increases hair count and improves hair growth with low risk of side effects.

The document concludes that management strategies for PCOS are important due to its common occurrence and associated health risks.

Inositol shows promise in treating PCOS and other health issues, but more research is needed.