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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Hair loss linked to higher heart disease risk in both men and women.

Skin fat helps with body temperature control and has other active roles in health.

Lower SHBG levels may increase the risk of PCOS.

Coats' Plus is a genetic disorder with eye abnormalities, brain calcification, poor growth, bone and skin issues, and movement disorders.

Excessive selenium from a supplement caused toxicity but patients recovered with care.

After menopause, women lose a lot of skin collagen, but estrogen replacement might improve skin health.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

The nanohybrid system significantly improved wound healing and showed strong antibacterial activity.

Skin problems are common and important signs of eating disorders and treating the eating disorder can improve these skin conditions.

Hormones might affect the skin condition hidradenitis suppurativa, but their exact role is unclear.

To diagnose Polycystic Ovarian Syndrome, two out of three signs—irregular periods, high male hormone levels, or cysts on the ovaries—are needed.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

Women with PCOS are more likely to have insulin resistance and obesity, especially those with the most severe type I PCOS.

Women with PCOS often have mood disorders and a lower quality of life, and treatment should focus on both physical and mental health.

Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.

Minoxidil may cause heart issues in animals and humans.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.

The document concludes that menopause should be seen as a natural part of aging and managed with personalized care and informed choices.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.