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Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Different types of skin cells play specific roles in development, healing, and cancer.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Stem cell niches support, regulate, and coordinate stem cell functions.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Obesity is linked to various skin problems and may increase the risk of skin cancer.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

An imbalanced gut and lack of biotin can cause hair loss in mice.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

The intensive conventional diet with exercise led to better long-term weight loss and health improvements than the very low calorie diet in obese type 2 diabetics.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Doctors need to be better prepared to assess and treat obesity in patients.

Most patients with chronic kidney disease have skin problems, which get worse as the disease progresses, and dialysis doesn't greatly reduce these issues.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Melatonin affects mouse skin and may regulate skin functions.

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

Psoriasis is linked to other autoimmune diseases and involves a specific inflammatory process.

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

Different skin stem cells help heal wounds, with hair follicle cells becoming more important over time.

Premature graying of hair may suggest health issues and currently lacks effective treatments.