34 citations
,
January 2014 in “Indian Dermatology Online Journal” This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.
34 citations
,
July 2010 in “Expert Opinion on Drug Delivery” This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.
33 citations
,
March 2018 in “Trends in cell biology” This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.
33 citations
,
January 2018 in “The Journal of Clinical Endocrinology & Metabolism” Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.
33 citations
,
September 2014 in “Reproductive Biology and Endocrinology” In this study, elevated afamin concentrations were associated with metabolic syndrome in young women, particularly those with insulin resistance, suggesting a potential predictive role for afamin in metabolic risk assessment.
33 citations
,
November 2008 in “European Journal of Pharmaceutical Sciences” This study found that St. John's wort treatment for two weeks induced finasteride metabolism and reduced its plasma exposure in healthy men.
33 citations
,
November 2007 in “JAT. Journal of applied toxicology/Journal of applied toxicology” In this study, human scalp hair grafted onto nude mice accurately reflected methyl mercury exposure, demonstrating its potential as a research model for monitoring mercury incorporation into human hair.
32 citations
,
April 2016 in “Journal of Obstetrics and Gynaecology Research” This study found that women with polycystic ovary syndrome phenotypes A and B had the highest prevalence of metabolic syndrome, and that the visceral adiposity index may help predict metabolic risk.
32 citations
,
April 2014 in “American Journal of Clinical Dermatology” People with psoriasis are more likely to have Metabolic Syndrome than those without psoriasis.
32 citations
,
November 2011 in “Reproductive Sciences” The study found that among young Brazilian women, the likelihood of metabolic syndrome in those with PCOS is strongly associated with BMI and the phenotype involving menstrual irregularity and hyperandrogenism.
31 citations
,
September 2015 in “BJUI” This study found that men aged 50 and older with clinical benign prostatic hyperplasia have a significantly higher prevalence of metabolic syndrome than those without the condition in the UK primary care population.
31 citations
,
January 2014 in “Clinical Endocrinology” This study found no significant differences in metabolic characteristics between different phenotypes of PCOS or between women with PCOS and healthy controls among reproductive-aged Iranian women.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.
31 citations
,
August 1975 in “Journal of Pharmaceutical Sciences” This study found that different species metabolized minoxidil into various products, with monkeys and humans showing similar profiles primarily excreting a glucuronide conjugate, while rats and dogs showed distinct differences.
31 citations
,
October 1971 in “Steroids” This study found that human beard hair follicles metabolize dehydroepiandrosterone into various compounds at significantly higher rates than those reported for human skin, suggesting unique metabolic processes in hair follicles.
30 citations
,
September 2017 in “Clinics in Dermatology” This article reviews the clinical and histological features of acanthosis nigricans and its associations with insulin resistance and other conditions, but highlights the need for more research on its classification, severity assessment, and treatment options.
30 citations
,
September 2017 in “Clinics in Dermatology” This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.
28 citations
,
June 2020 in “Poultry Science” This study found that injecting L- or DL-Methionine into chick embryos increased feather growth and follicle development by activating the Wnt/β-catenin signaling pathway, with no difference between the two methionine forms.
28 citations
,
November 2013 in “The FASEB journal” In this study, a low-methionine diet significantly improved the health and physical traits of cystathionine β-synthase-deficient mice, contrasting with negative effects on mice with partial deficiency.
28 citations
,
January 2016 in “Dermatology” This study observed that methotrexate combined with low- to moderate-dose oral corticosteroids may effectively treat severe alopecia areata, though long-term maintenance is often necessary due to relapse after tapering.
28 citations
,
July 2015 in “American Journal of Clinical Dermatology” This study found a higher prevalence of metabolic syndrome in patients with lichen planus, especially those with mucosal involvement, which is associated with increased cardiovascular and diabetes risk.
28 citations
,
March 1973 in “The Journal of Clinical Endocrinology & Metabolism” This study found that hair follicles from balding men show significant metabolic differences compared to those from non-balding individuals, particularly in their ability to process dehydroepiandrosterone.
27 citations
,
May 2011 in “Journal of dermatology” In this study, methylprednisolone pulse therapy was found to be effective for severe alopecia areata patients, especially those with a short disease duration or plurifocal type.
27 citations
,
May 2010 in “Dermatologic surgery” This study found that photodynamic therapy with methyl 5-aminolevulinic acid was ineffective for treating alopecia totalis, even with microneedle rolling to enhance drug delivery.
26 citations
,
September 2014 in “Neuroscience Letters” This study found that metformin did not prevent gentamicin-induced hearing loss and even worsened auditory threshold shifts and caused adverse effects at higher doses in guinea pigs.
26 citations
,
June 2023 in “International Journal of Bioprinting” In this study, an innovative composite hydrogel incorporating methylene blue-loaded nanoparticles was developed for 3D-printed wound dressings, showing improved mechanical properties, excellent antibacterial effects, and enhanced skin healing in mice.
26 citations
,
January 2016 in “Indian journal of endocrinology and metabolism” In this randomized trial, metformin and pioglitazone both improved certain clinical and metabolic indices in women with PCOS, with pioglitazone showing potential as an alternate treatment for those intolerant to metformin.
25 citations
,
June 2012 in “Endocrine” This review discusses emerging concepts in PCOS from the AEPCOS 2010 meeting and reports no clinical findings; it suggests that the transition of care in congenital adrenal hyperplasia could inform PCOS adolescent care.
25 citations
,
June 2015 in “Acta dermato-venereologica” Methotrexate can help some kids with severe hair loss regrow hair.
25 citations
,
January 2005 in “Pediatric Dermatology” This article discusses the use of methotrexate for treating generalized pustular psoriasis in a 2-year-old child, providing a specific case study but reporting no new clinical results.