6 citations
,
October 2010 in “Gynecological Endocrinology” This study found that relatives of women with symptoms of oligo-amenorrhoea and hirsutism experienced higher rates of hirsutism, menstrual disorders, infertility, childlessness, diabetes, and hypertension compared to relatives of symptomless women.
6 citations
,
July 2009 in “Biomolecules & therapeutics” This study found that combining MSM with MAP significantly enhanced hair growth in mice, comparable to or better than minoxidil, due to increased intradermal retention of MAP.
6 citations
,
March 2009 in “BMC Public Health” In this study, higher levels of the sulfur-containing gas CH3SCH3, associated with oral malodor, were linked to MPB in elderly Japanese males, particularly when gastrointestinal and metabolic disorders were present.
6 citations
,
July 2007 in “Organic Process Research & Development” This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.
6 citations
,
October 1989 in “PubMed” This study describes optimized methods for culturing hair cells from 4-day-old C3H mice, leading to successful maintenance of hair-specific cytoskeletal protein expression under the experimental conditions.
6 citations
,
June 1983 in “Cancer” This study found that a chemotherapy regimen combining CMFVP and ACP treatments for unresectable metastatic breast cancer yielded a 66.7% overall response rate, with premenopausal women responding more favorably than postmenopausal women.
5 citations
,
June 2025 in “Advances in Therapy” This narrative review reports that metformin, traditionally used for type 2 diabetes management, may offer therapeutic benefits for various skin disorders, such as acne, rosacea, and psoriasis, due to its anti-inflammatory and other beneficial properties, warranting further exploration in dermatology.
5 citations
,
June 2024 in “Cureus” In a study involving adults with mild to moderate dandruff, researchers observed that post-hair wash interventions significantly reduced dandruff as measured by three assessment methods, showing substantial reliability and correlation, which supports their use in clinical settings for evaluating scalp dandruff treatments.
5 citations
,
March 2023 in “Archives of dermatological research” This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.
5 citations
,
January 2018 in “Acta dermato-venereologica” This study identified an association between premature hair greying and larger waist circumference among young healthy subjects.
5 citations
,
January 2024 in “JID Innovations” In this study, researchers identified significant differences in protein expression patterns in scalps affected by central centrifugal cicatricial alopecia, notably upregulation of immune pathways and fibrosis markers and downregulation of metabolic proteins, suggesting unique disease mechanisms and potential therapeutic targets.
5 citations
,
March 2023 in “International Journal of Trichology” This study reported a similar prevalence of metabolic syndrome in patients with alopecia areata as in healthy controls, with no statistically significant differences observed.
5 citations
,
May 2022 in “Biomedicines” This study found that the green alga Botryococcus terribilis and its novel compounds significantly promoted hair growth marker gene expression in hair follicle dermal papilla cells without cytotoxic effects.
5 citations
,
December 2021 in “Skin Pharmacology and Physiology” In this study, metformin promoted hair follicle regeneration in vitro by enhancing the hair inductive capability of dermal cells, warranting further exploration for pattern hair loss treatment.
5 citations
,
February 2021 in “JCPSP. Journal of the College of Physicians & Surgeons Pakistan” This study investigated the relationship between early-onset androgenetic alopecia and metabolic syndrome in younger males, but the abstract does not report specific results.
5 citations
,
January 2021 in “Daru” This case report highlights a rare instance of severe multi-organ involvement following a single dose of methotrexate for ectopic pregnancy, requiring intensive care but ultimately successfully treated with leucovorin and supportive care.
5 citations
,
July 2020 in “PubMed” This study found that EE/CPA and EE/DES were both effective in reducing hirsutism in patients with PCOS, with no additional benefit from adding low-dose metformin.
5 citations
,
August 2018 in “Ocular immunology and inflammation” This study observed potential racial and gender differences in methotrexate side effects among uveitis patients, noting gastrointestinal issues were more common in males and Caucasians, while African Americans experienced more hair loss.
5 citations
,
February 2018 in “Experimental Dermatology” This study describes a method inspired by hair transplantation techniques to efficiently isolate eccrine sweat glands from human scalp hair grafts, potentially facilitating further research into their function.
5 citations
,
January 2018 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH” In this study, flat feet were identified as a potential indicator of metabolic syndrome in obese individuals, with significant associations noted for striae distensae and candida intertrigo with abdominal obesity.
5 citations
,
December 2016 in “Journal of skin and stem cell” This study found that patients with cutaneous lichen planus had a higher risk of metabolic syndrome, dyslipidemia, diabetes mellitus, and hypertension compared to controls.
5 citations
,
January 2016 in “Indian dermatology online journal” This case report describes a 25-year-old male with multiple keratoacanthomas that responded to intralesional methotrexate and oral acitretin treatment.
5 citations
,
January 2006 in “Journal of obstetrics and gynaecology” Metformin can cause hair loss in some women with PCOS.
5 citations
,
July 1999 in “Journal of Anatomy” This study observed that methylene blue staining and zinc iodide-osmium tetroxide techniques effectively revealed anatomical details of intraepidermal nerve fibre endings in the rat's mystacial pad, suggesting their potential role in mechanoreception.
5 citations
,
February 1997 in “Bioorganic & Medicinal Chemistry” This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.
5 citations
,
May 1983 in “Australian journal of biological sciences” This study found that concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibers in sheep, whereas reduced glutathione did not have the same effect.
5 citations
,
December 1981 in “PubMed” This study describes a case where metoprolol was associated with reversible telogen effluvium, suggesting a similar mechanism of alopecia as seen with other beta-adrenoceptor antagonists.
5 citations
,
January 1961 in “PubMed” This study found that the lipid composition of the epidermis varies significantly throughout the hair growth cycle and after applying methylcholanthrene, with notable differences observed between hyperplastic and carcinomatous conditions.
4 citations
,
December 2023 in “Frontiers in Pharmacology” This study found that topical metformin was as effective as triple combination cream in reducing melasma severity, with minimal adverse events.
4 citations
,
January 2017 in “Acta Endocrinologica” This study found that both finasteride and metformin effectively reduced androgen levels and insulin resistance parameters in women with PCOS, without clear evidence of one treatment being superior.