September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, researchers investigated the formation of spherical crystals of minoxidil in various alcoholic solvents, discovering new types like spherulite aggregates and a unique butterfly-shaped crystal, with the spherulite aggregates showing improved powder flow properties compared to other forms.
1 citations
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August 2019 in “IntechOpen eBooks” This article discusses the use of mesotherapy in dentistry and reports no new clinical results, emphasizing the need for further research on its applications for oral problems.
7 citations
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December 2024 in “International Journal of Pharmaceutics” In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.
April 2024 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)” This study clarifies the fundamental aspects of intradermotherapy or mesotherapy, tracing its historical development and highlighting its benefits as well as the negative consequences of improper use, specifically addressing its decline due to severe side effects from treatment errors.
September 2023 in “Journal of Fluid Mechanics” This study developed a model using homogenization-based framework to quantify solvent and solute flow across Janus membranes, aiming to better understand interface phenomena like osmosis and phoresis by examining micro- and macro-scale behaviors.
5 citations
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July 2025 in “Journal of Clinical Medicine” This study reviewed existing literature on mesotherapy and developed evidence-based guidelines, which support its standardized and safe use for osteoarticular pain, rehabilitation, and dermatology, marking a shift from practice based on personal beliefs to an evidence-based approach.
July 2020 in “IP International Journal of Maxillofacial Imaging/International journal of maxillofacial imaging/IP International journal of maxillofacial imaging” The authors concluded that mesotherapy is a new, effective, and safer dermatologic treatment option for conditions like alopecia, skin rejuvenation, and hyperpigmentation due to its efficiency and reduced treatment time.
January 2022 in “Physics and Chemistry of Liquids” This study investigated the solubility of minoxidil in various solvent mixtures and applied multiple models to understand solute-solvent interactions and energy dynamics.
3 citations
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October 2014 in “Pharmaceutical Development and Technology” This study found that an optimized microemulsion for minoxidil with high solubility, permeation flux, and skin deposition can be achieved with specific low and high levels of certain surfactants and co-solvents.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that dissolving microneedle array patches containing mesoporous silica nanoparticles can deliver antigen-loaded nanoparticles into mice effectively, inducing strong immune responses similar to traditional subcutaneous injection.
September 2025 in “Crystal Growth & Design” This study investigated the morphology and growth mechanisms of spherical crystal aggregates of minoxidil in various alcoholic solvents, finding that a n-butanol–ethyl acetate mixture produces unique spherulite aggregates with improved powder characteristics.
This study reports that hair mesotherapy can achieve positive clinical outcomes for scalp diseases, particularly when used by expert dermatologists. It is primarily used alongside standard treatments, and as a standalone option only when other treatments are contraindicated or ineffective.
July 2026 in “Organoid Research” This review focuses on hydrogel microsphere-mediated strategies to improve organoid culture by addressing deficiencies in extracellular matrix organization, potentially enhancing the physiological accuracy and clinical translatability of osteomuscular in vitro models as reported in this study.
49 citations
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May 2020 in “The Scientific World JOURNAL” This position paper from the Italian Mesotherapy Society discusses the application of intradermal therapy based on scientific evidence, highlighting its potential benefits for certain localized conditions, although it acknowledges the lack of randomized clinical trials for some uses.
June 2007 in “CRC Press eBooks” Aesthetic mesotherapy can improve the appearance of the face and hair.
December 2025 in “Brazilian Journal of Chemical Engineering”
1 citations
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April 2021 in “Aesthetic Cosmetology and Medicine” This article reviews various applications and substances in mesotherapy for skin conditions and discusses the benefits of series treatments, reporting no new clinical results.
20 citations
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August 2019 in “Journal of Cosmetic Dermatology” This study reviewed literature from 1992 to 2018 to document mesotherapy-related complications and their management, concluding that standardized therapy parameters are needed to better evaluate the safety profile and minimize risks of adverse reactions.
March 2025 in “Scientific Reports” This study evaluated a menthol-based microemulsion for transdermal delivery of finasteride and silodosin, finding that it enhanced skin permeation and flux compared to aqueous solutions, suggesting a promising method for managing benign prostatic hyperplasia.
January 2025 in “Acta Scientific Women s Health” This review examines the diverse uses of mesotherapy in dermatology, noting its efficacy in enhancing skin hydration and treating conditions such as hyperpigmentation, hair loss, and acne scarring, while highlighting its potential to optimize overall skin health.
23 citations
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March 2021 in “Gels” This study found that minoxidil solubilized in gelatin-containing microemulsions resulted in over 5% of the drug remaining in porcine skin, significantly more than the reference gel.
January 2014 in “Jaypee Brothers Medical Publishers (P) Ltd. eBooks” Mesotherapy might help with hair and scalp problems.
February 2026 in “ACS Omega” This study developed a multifunctional hydrogel, QTMP-Gel, which significantly accelerated wound healing in an oral mucositis hamster model by providing antioxidant and antibacterial effects, reducing inflammation, and controlling infection.
January 2025 in “New Journal of Chemistry” In this study, researchers developed hollow mesoporous organosilica nanoparticles and confirmed their synthesis using IR spectroscopy, then evaluated the nanoparticles for endocytosis and biocompatibility, although specific results of these tests are not reported in the abstract.
April 2014 in “Journal of Aesthetic Nursing” This article provides descriptive results indicating high client satisfaction and good tolerance associated with mesotherapy in treating hair loss, based on the author's personal experience with clients.
September 2022 in “Pharmacy Today”
January 2016 in “Springer eBooks” The document concludes that there are various causes and treatments for hair loss, with hair transplantation being a notable option.
April 2009 in “Dermatologic Surgery” The document concludes that the first book on mesotherapy lacks convincing evidence, the second book is good for beginners in facial rejuvenation, and the third book is valuable for understanding complications in skin surgery.
September 2016 in “Hair transplant forum international” This abstract provides author information and location affiliations for a study conducted in Bangkok, Thailand, but it does not include reported results or study details.
August 2025 in “Stem Cells” This study developed a molecular systems architecture to map the complex interactions between mesenchymal stromal cells and their microenvironment, providing a framework for future predictive models that could enhance therapeutic strategies and reduce adverse effects.