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    Glossary Mesenchymal Stem Cell Secretome

    collection of bioactive molecules secreted by mesenchymal stem cells

    The Mesenchymal Stem Cell (MSC) Secretome refers to the collection of bioactive molecules, such as proteins, lipids, and nucleic acids, that are secreted by mesenchymal stem cells. These molecules play a crucial role in cell signaling, tissue repair, and immune modulation, making the MSC secretome a significant focus in regenerative medicine and therapeutic research.

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    1. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017 · 773 citations
    2. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021 · 26 citations
    3. Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study Stem Cell Research & Therapy · 2025
    4. CASE REPORT: SUCCESSFUL TREATMENT OF ALOPECIA WITH UMBILICAL CORD MESENCHYMAL STEM CELL AND MESENCHYMAL STEM CELL-DERIVED SECRETOME COMBINATION Cytotherapy · 2024
    5. THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES International Journal of Applied Pharmaceutics · 2026
    6. Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-II 2024
    7. Limbal Mesenchymal Stem Cell Secretome as Potential Adjuvant Therapy for Ocular Alkali Injury 2022
    8. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome Cells · 2019 · 271 citations
    9. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review Stem Cell Research & Therapy · 2025 · 9 citations
    10. Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia Biosaintifika Journal of Biology & Biology Education · 2024
    11. Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics Cell proliferation · 2023 · 3 citations
    12. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration Stem Cells International · 2018 · 9 citations
    13. Modern aspects of external application and prospects of using the secretome of mesenchymal stem cells (review) Drug development & registration · 2024
    14. Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review Journal of Biomedical Science · 2022 · 2 citations
    15. Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ Biosaintifika Journal of Biology & Biology Education · 2024
    16. Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial Preprints.org · 2026
    17. Stem Cell Secretome for Skincare: Of Cell Types, Exosomes, Extracellular Vesicles, and Soluble Fractions Preprints.org · 2025
    18. Synergistic effects of mesenchymal stem cells and their secretomes with scaffolds in burn wound healing: a systematic review and meta-analysis of preclinical studies Journal of Translational Medicine · 2025 · 16 citations
    19. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023
    20. Evaluation of the phenotypic, proliferative and secretory profile of mesenchymal stem cells from adipose tissue captured by laser-assisted liposuction Digital Library of Theses and Dissertations (Universidade de São Paulo) · 2023
    21. The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells (SH-MSCs) on IL-6 and TGF- β Gene Expression (Experimental Study in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole) International journal of multidisciplinary research and analysis · 2023
    22. Dual Traditional Chinese Medicine-Preconditioned Stem Cell Secretomes in Coaxial Electrospun Nanofibers Synergistically Accelerate Diabetic Wound Regeneration bioRxiv (Cold Spring Harbor Laboratory) · 2026
    23. Immortalized human hair follicle-derived mesenchymal-like stromal cells for the long-term production of scalable Immunomodulatory and regenerative secretome Stem Cell Research & Therapy · 2025 · 1 citations
    24. The Autologous Hair Follicle and Its Secretome: A Multipotent Source for Cell-Based and Cell-Free Regenerative Therapies International Journal of Molecular Sciences · 2026
    25. Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration Experimental and Molecular Medicine · 2019 · 14 citations
    26. A Comparative Study on Adipose-Derived Mesenchymal Stem Cells Secretome Delivery Using Microneedling and Fractional CO2 Laser for Facial Skin Rejuvenation [Response to Letter] Clinical Cosmetic and Investigational Dermatology · 2023
    27. Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation International Journal of Molecular Sciences · 2019 · 166 citations
    28. Secretome-Based Therapy Promotes Epidermal Thickness Recovery and Follicular Regrowth in Fluconazole-Induced Alopecia in Rats International Journal of Cell and Biomedical Science · 2025
    29. Avaliação do perfil fenotípico, proliferativo e secretório de células-tronco mesenquimais do tecido adiposo captadas por lipoaspiração assistida por laser 2023
    30. Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss Springer eBooks · 2016