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    Research 481–510 of 683

    1. Pharmacogenetics of the Androgen Metabolic Pathway 2010
    2. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation Nature genetics · 2000 · 694 citations
    3. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    4. Drug Repurposing for Rare Diseases Trends in Pharmacological Sciences · 2021 · 246 citations
    5. Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases Cell · 2020 · 227 citations
    6. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth International journal of reproductive medicine · 2014 · 222 citations
    7. Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ Proceedings of the National Academy of Sciences of the United States of America · 2013 · 218 citations
    8. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex Nature · 2010 · 199 citations
    9. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation The Journal of Cell Biology · 2001 · 195 citations
    10. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    11. Biotin and biotinidase deficiency Expert Review of Endocrinology & Metabolism · 2008 · 166 citations
    12. LPA-producing enzyme PA-PLA<sub>1</sub>α regulates hair follicle development by modulating EGFR signalling The EMBO Journal · 2011 · 151 citations
    13. Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata The American Journal of Human Genetics · 2007 · 143 citations
    14. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016 · 119 citations
    15. Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia Proceedings of the National Academy of Sciences · 2001 · 103 citations
    16. Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007 · 101 citations
    17. Phospholipase C 1 is required for skin stem cell lineage commitment The EMBO Journal · 2003 · 101 citations
    18. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    19. Mutations in γ-secretase subunit–encoding PSENEN underlie Dowling-Degos disease associated with acne inversa Journal of Clinical Investigation · 2017 · 87 citations
    20. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    21. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007 · 75 citations
    22. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    23. Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work European Journal of Medicinal Chemistry · 2019 · 70 citations
    24. STUB1 mutations in autosomal recessive ataxias – evidence for mutation-specific clinical heterogeneity Orphanet Journal of Rare Diseases · 2014 · 65 citations
    25. Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008 · 62 citations
    26. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    27. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions Journal of Investigative Dermatology · 2015 · 56 citations
    28. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015 · 55 citations
    29. Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling Journal of Investigative Dermatology · 2015 · 53 citations
    30. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis Developmental Biology · 2003 · 53 citations