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930-960 / 1000+ results![Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review](/images/research/643c584d-a3c0-442c-a851-a5cf68d756dd/small/16592.jpg)
research Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review
Men and women respond differently to drugs for COVID-19, high cholesterol, and diabetes, which suggests a need for personalized treatments.
![Vitamin D Receptor: New Assignments for an Already Busy Receptor](/images/research/8be41e14-89c3-4498-8667-6ea4973d21be/small/30938.jpg)
research Vitamin D Receptor: New Assignments for an Already Busy Receptor
The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.
![Minireview: Vitamin D Receptor: New Assignments for an Already Busy Receptor](/images/research/eb9785cf-89c7-4e49-83d9-12ca2523da44/small/30939.jpg)
research Minireview: Vitamin D Receptor: New Assignments for an Already Busy Receptor
The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.
![Common Variants in the Sex Hormone-Binding Globulin Gene (SHBG) and Polycystic Ovary Syndrome (PCOS) in Mediterranean Women](/images/research/e3954850-f2ee-456f-99b7-f7c46dc0d0e6/small/14659.jpg)
research Common Variants in the Sex Hormone-Binding Globulin Gene (SHBG) and Polycystic Ovary Syndrome (PCOS) in Mediterranean Women
Certain genetic variations in the SHBG gene are linked to an increased or decreased risk of PCOS in Mediterranean women.
![The Pharmacology of Methotrexate](/images/research/d3374f23-d731-4db1-a827-7e740d421d95/small/25352.jpg)
research The Pharmacology of Methotrexate
Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
![Dermatoses of Pregnancy: Clues to Diagnosis, Fetal Risk, and Therapy](/images/research/e808f29b-b586-4ad7-b7b2-636d41f8c916/small/24675.jpg)
research Dermatoses of Pregnancy: Clues to Diagnosis, Fetal Risk, and Therapy
The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.
![Mitoxantrone](/images/research/fde9b80a-bf95-47fd-9cc6-1fdc2a7696ba/small/22707.jpg)
research Mitoxantrone
Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.
![The Transcriptional Landscape of Seasonal Coat Color Moult in the Snowshoe Hare](/images/research/e76d3a4d-eb4a-4896-a21c-9e2107eaf507/small/34889.jpg)
research The Transcriptional Landscape of Seasonal Coat Color Moult in the Snowshoe Hare
Researchers found genes that control hair color and growth change before the visible coat color changes in snowshoe hares.
![Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods](/images/research/751791bf-251a-4e1a-ae8d-a481bf4f6ad5/small/17538.jpg)
research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods
The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.
![Diuretics](/images/research/f69b688e-b017-40f7-b021-07b4aa21397f/small/20219.jpg)
research Diuretics
Diuretics help the body get rid of excess salt and water by acting on the kidneys in different ways.
![Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs](/images/research/0847b672-a954-484e-ad79-601231bda6df/small/26493.jpg)
research Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs
Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.
![Whole-Genome Bisulfite Sequencing of Goat Skins Identifies Signatures Associated with Hair Cycling](/images/research/6711c087-e0d9-4613-814a-80c102c812ae/small/29057.jpg)
research Whole-Genome Bisulfite Sequencing of Goat Skins Identifies Signatures Associated with Hair Cycling
DNA methylation changes are linked to hair growth cycles in goats.
research Comparison of Pemetrexed and Docetaxel as Salvage Chemotherapy for the Treatment of Non-Small-Cell Lung Cancer After the Failure of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors
Pemetrexed is as effective as docetaxel but has fewer side effects for treating nonsmall-cell lung cancer after EGFR-TKI therapy failure.
![Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin](/images/research/7e595fd9-d258-4169-a0ff-abbc7bcb318f/small/34072.jpg)
research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin
Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.
![The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men](/images/research/0fe0a6fe-e727-4af3-9925-5b1a129b4e23/small/2866.jpg)
research The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men
St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.
![Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos](/images/research/0d67d773-a26d-4392-a6c2-31036b742204/small/19322.jpg)
research Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos
Akt2 protein is essential for normal cell division in early mouse embryos.
![Localization of Varicella-Zoster Virus Nucleic Acids and Proteins in Human Skin](/images/research/4c242a1a-716b-4b78-a342-05a6aedc66bd/small/21044.jpg)
research Localization of Varicella-Zoster Virus Nucleic Acids and Proteins in Human Skin
The research found that chickenpox virus spreads in skin through blood then to skin cells, while shingles virus moves from nerves to hair follicle areas before infecting skin cells.
![Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression](/images/research/12ea3709-959c-4e62-ae6b-856be3a94623/small/3952.jpg)
research Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression
AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.
![Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling](/images/research/982ad3a2-f48a-4a95-8749-b714e23ecece/small/4727.jpg)
research Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling
Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.
![The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates](/images/research/36936fd4-862a-4936-9996-17fdf7e9ee1c/small/33997.jpg)
research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates
SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
![Fetal Alcohol Syndrome: Current Status of Pathogenesis](/images/research/4b9a79ee-1d5a-46dc-89e6-884dac08835f/small/34307.jpg)
research Fetal Alcohol Syndrome: Current Status of Pathogenesis
The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.
research Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Produced Anxiolytic and Antidepressant-Like Behavioral Effects
Increasing TSPO in the brain reduces anxiety and depression.
![Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase](/images/research/eacb0444-f99d-4e57-b7ac-cce929dbf2ca/small/29268.jpg)
research Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase
Telogen is an active phase with important biological processes, not a resting phase.
![Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen](/images/research/5aea67fd-386e-4483-b4f2-1934f4a79f95/small/5151.jpg)
research Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen
Impaired autophagy may cause hair loss by triggering early catagen.
![The Endocannabinoid Tone Regulates Human Sebocyte Biology](/images/research/5804816e-0e9a-460f-a026-6f7d7874e7a9/small/16103.jpg)
research The Endocannabinoid Tone Regulates Human Sebocyte Biology
The endocannabinoid system affects oil production and inflammation in skin cells.
![TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model](/images/research/d8b49375-373d-4879-a217-68b4aaa6712e/small/13986.jpg)
research TSPO Activation Modulates the Effects of High Pressure in a Rat Ex Vivo Glaucoma Model
Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
![Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules](/images/research/92794cd7-58be-4ad0-88c6-b73626a27318/small/22923.jpg)
research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules
PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.
![A Novel Splice Site Mutation in LIPH Identified in a Japanese Patient with Autosomal Recessive Woolly Hair](/images/research/c59fe8d3-4fd5-41d8-ad44-8e4b853ae5ca/small/16099.jpg)
research A Novel Splice Site Mutation in LIPH Identified in a Japanese Patient with Autosomal Recessive Woolly Hair
Researchers found a new genetic mutation linked to a hair condition in a Japanese boy.
![Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in This Gene Family for Its Expression in the Adult Mouse Tail and Ear](/images/research/82b3e1e4-bba7-4144-baaa-402fc3eb1909/small/35154.jpg)
research Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in This Gene Family for Its Expression in the Adult Mouse Tail and Ear
A new gene, mrp4, is found in mice and may play a unique role in hair follicle development in tails and ears.