January 2026 in “Scientific Reports” In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.
April 2024 in “Frontiers in cellular and infection microbiology” This review highlights evidence supporting the potential of blue light therapy as a non-invasive treatment for managing skin and hair conditions by modulating interactions between the skin microbiome and its host.
January 2024 in “Molecules (Basel. Online)” In this study, researchers examined juglone's potential as a restoring agent for hair keratin damaged by permanent or bleaching treatments, finding that juglone formed Michael adducts with cysteine residues, leading to a more regular hair surface as observed via IR spectroscopy and SEM analysis.
December 2023 in “Frontiers in plant physiology” This review discusses recent findings on how root hairs and root exudate secretion play critical roles in recruiting nitrogen-fixing bacteria, potentially aiding the development of cereal crops that can use atmospheric nitrogen, which may reduce reliance on synthetic fertilizers.
December 2023 in “The journal of cell biology/The Journal of cell biology” This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.
August 2023 in “Scientific reports” In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.
January 2023 in “Theranostics” This study demonstrated that a mechanical-chemical cascade involving dermal cell contraction and the activation of Piezo1 in epidermal cells is crucial for initiating interactions necessary for hair follicle regeneration in skin organoids.
May 2021 in “GSC Advanced Research and Reviews” This review discusses recent advances in the understanding of follicular melanogenesis and its pathological changes, particularly how these changes are associated with specific disease phenotypes, but it reports no new results.
September 2004 in “Experimental dermatology” This study found that normal murine hair follicles are direct targets for melatonin bioregulation, expressing receptors that are regulated in a hair cycle-dependent manner, influencing keratinocyte apoptosis.
May 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
January 2025 in “PLoS ONE” This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.
November 2024 in “The Journal of Cell Biology” This study revealed that basement membrane dynamics are crucial to hair follicle development, influencing progenitor cell behavior and cell division patterns in developing mouse hair follicles.
April 2024 in “Frontiers in physiology” This review article examines recent studies on the role of diverse immune cells in forming an active niche for hair follicles, offering new insights into hair growth and related diseases.
This study found that the NuMA protein's microtubule-binding domain is essential for proper spindle orientation and differentiation in keratinocytes, affecting skin and hair development in mice.
44 citations
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June 2018 in “Journal of Cellular Physiology” This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.
17 citations
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February 2019 in “PubMed” This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.
14 citations
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January 2025 in “AAPS PharmSciTech” This review highlights the promising potential of microemulsions and nanoemulsions in (trans)dermal drug delivery, noting a gap in understanding their distinct mechanisms and composition-related effects on skin permeability, while emphasizing the limited clarity on mesostructures and cosolvent impacts.
4 citations
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January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
1 citations
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March 2014 in “TURKDERM” This review discusses the fundamental features of hair follicle biology and its clinical importance, but it reports no new clinical results.
March 2024 in “International journal of molecular sciences” In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.
March 2017 in “InTech eBooks” This source provides a comprehensive review of acne vulgaris, highlighting its pathophysiology, epidemiology, molecular mechanisms, and treatment options, emphasizing the significance of addressing acne's psychosocial burden for adolescents and beyond.
28 citations
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September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
1 citations
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March 2023 in “International Journal of Health and Pharmaceutical Medicine” This review summarizes the link between acne pathogenesis and skin barrier dysfunction, noting that more severe acne correlates with greater skin barrier damage, but reports no new clinical results.
September 2023 in “Journal of Fluid Mechanics” This study developed a model using homogenization-based framework to quantify solvent and solute flow across Janus membranes, aiming to better understand interface phenomena like osmosis and phoresis by examining micro- and macro-scale behaviors.
209 citations
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September 2008 in “Dermatologic Therapy” This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
50 citations
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December 2020 in “Bioactive Materials” This study suggests that a sandwich-structured wound dressing with bioceramic and polylactic acid layers may improve burn wound healing by absorbing exudates and promoting hair follicle regeneration.
32 citations
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May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
32 citations
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May 2018 in “The Plant Cell” This article discusses the crucial role of root hairs in water and nutrient uptake from soil and reports no new findings.
25 citations
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July 2019 in “Journal of drug delivery science and technology” This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.
21 citations
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September 2019 in “International Journal of Nanomedicine” RADA16-I can effectively deliver and release mangiferin, improving its solubility and bioavailability.