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    Glossary Melanogenesis

    process of producing melanin in skin and hair cells

    Melanogenesis is the process by which the skin and hair produce melanin, the pigment responsible for their color. This process occurs in specialized cells called melanocytes and involves a series of biochemical reactions, primarily catalyzed by the enzyme tyrosinase. Melanogenesis is influenced by genetic factors, UV exposure, and hormonal changes, and plays a crucial role in protecting the skin from UV radiation.

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    1. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth 1993 · 210 citations
    2. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle 1994 · 161 citations
    3. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth. 1993 · 109 citations
    4. INTERACTION OF α-MELANOCYTE-STIMULATING HORMONE, MELATONIN, CYCLIC AMP AND CYCLIC GMP IN THE CONTROL OF MELANOGENESIS IN HAIR FOLLICLE MELANOCYTES IN VITRO Journal of Endocrinology · 1981 · 53 citations
    5. Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic–Pituitary–Adrenocortical Axis Elements and Melanogenesis PLoS ONE · 2014 · 40 citations
    6. Coming of Age of Melanogenesis-Related Proteins Archives of Pathology & Laboratory Medicine · 2002 · 37 citations
    7. The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine Biomaterials · 2014 · 36 citations
    8. Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis 2013 · 29 citations
    9. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts Laboratory Investigation · 2006 · 27 citations
    10. Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase Molecules · 2015 · 25 citations
    11. Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis 2019 · 23 citations
    12. Quercetin stimulates melanogenesis in hair follicle melanocyte of the mouse. PubMed · 2013 · 20 citations
    13. Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo Biological & pharmaceutical bulletin · 2007 · 19 citations
    14. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster International Journal of Molecular Sciences · 2016 · 18 citations
    15. Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (Oryza sativa L. cv. Pieisu 1 CMU) for Cosmetic Application Plants · 2023 · 18 citations
    16. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    17. N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth 2011 · 15 citations
    18. HGF/SF Increases Number of Skin Melanocytes but Does Not Alter Quality or Quantity of Follicular Melanogenesis PloS one · 2013 · 14 citations
    19. EFFECTS OF α-MELANOCYTE-STIMULATING HORMONE AND [8-ARGININE]-VASOTOCIN UPON MELANOGENESIS IN HAIR FOLLICLE MELANOCYTES IN VITRO Journal of Endocrinology · 1981 · 12 citations
    20. Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells Archives of Pharmacal Research · 2018 · 11 citations
    21. Pimecrolimus increases the melanogenesis and migration of melanocytes <i>in vitro</i> Korean Journal of Physiology and Pharmacology · 2017 · 8 citations
    22. Synergistic effect of rice bran extract and extremely low-frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis Bioelectromagnetics · 2018 · 6 citations
    23. Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains PLoS ONE · 2018 · 6 citations
    24. Melanogenesis‐promoting effect of <i>Cirsium japonicum</i> flower extract in vitro and ex vivo International Journal of Cosmetic Science · 2021 · 4 citations
    25. CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis Journal of Dietary Supplements · 2014 · 3 citations
    26. Ethanol extract of medicinal herbal mixture accelerates hair growth and melanogenesis in vivo and in vitro The Korea Journal of Herbology · 2018 · 2 citations
    27. Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity Journal of Cellular and Molecular Medicine · 2025 · 1 citations
    28. Cyclic Nucleotides and the Mediation of Melatonin-induced Inhibition of Melanogenesis in Mammals Elsevier eBooks · 1981 · 1 citations
    29. Plerixafor Engages β-Arrestin-Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin-MITF Activation Current Issues in Molecular Biology · 2026
    30. Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation Preprints.org · 2026